Archive

Latest publication (January 2011)

Critical Care Medicine 2011 vol 39

Tømte Øystein, Tomas Drægni, Arild Mangschau, Dag Jacobsen, Bjorn Auestad B. Kjetil Sunde

A comparison of core and surface cooling techniques in cardiac arrest survivors

Critical Care Medicine, 2011;36:443-449


Latest publication (February 2011)

Annals of the Rheumatic Diseases Feb2011

Thomas Schwartz, Helga Sanner, Trygve Husebye, Berit Flatø, Ivar Sjaastad

Cardiac dysfunction in juvenile dermatomyositis: a case-control study

In Annals of the Rheumatic Diseases
Ann Rheum Dis doi:10.1136/ard.2010.137968

Cardiovascular Research Advance Access


The Heart Prize 2011

Nasjonalforeningen for folkehelse LOGO

The Norwegian Council for Cardiovascular Diseases has honored professor Geir Christensen for his research on the importance of hormone production in the heart, and his efforts to establish the Center for Heart Failure Research. His Majesty King Harald presented the Heart Prize 2011 to Geir Christensen at an award ceremony in Oslo.


Latest publication (February 2011)

Cardiovascular Research Advance Access

Mathis K. Stokke, Sarah J. Briston, Guro F. Jølle, Isma Manzoor, William E. Louch, Leiv Øyehaug, Geir Christensen, David A. Eisner, Andrew W. Trafford, Ole M. Sejersted, and Ivar Sjaastad

Ca2+ wave probability is determined by the balance between SERCA2-dependent Ca2+ reuptake and threshold SR Ca2+ content.

In Cardiovascular Research Advance Access published February 7, 2011
doi:10.1093/cvr/cvr013


Research Groups

People

Please use the links to find out more about our competence.

Disease mechanisms of heart failure
Professor Ivar Sjaastad

  • Subcellular and molecular organization
  • Electrical remodeling
  • Stiffness and calcium signaling
  • Contractile dyssynchrony
  • Skeletal muscle fatigue

Cellular and molecular biology of myocardial hypertrophy and heart failure
Professor Geir Christensen
- Cytokines, proteoglycans and stress-induced myocardial hypertrophy and heart failure

Role of the natriuretic peptides in hypertensive heart disease
Professor Alessandro Cataliotti

Cardiomyocyte function in health and disease
William E. Louch

Structural studies of P type-ATPases and intrinsically disordered proteins involved with metal and pH homeostasis
Senior Scientist Jens Preben Morth

Myocardial remodeling and reverse remodeling in pressure overload
Professor Theis Tønnessen

PATH-Pregnancy acute atherosis and future cardiovascular disease
Professor Annetine Staff


Available Methods

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Please use the links to the left for some available methods at the Institute for Experimental Medical Research (IEMR).

Ca wave


News archive 2009


Disputas: Cand.scient. Halvor Kjeang Mørk (December 2009)

Disputas: Cand.scient. Halvor Kjeang Mørk ved Fakultetsdivisjon Ullevål universitetssykehus vil forsvare sin avhandling for graden ph.d. (philosophiae doctor) "Cellular Mechanisms of Heart Failure Progression"
Tid og sted: 18. des. 2009 12:15, Auditoriet i Kreftsenteret, Oslo universitetssykehus Ullevål, Kirkeveien 166


Disputas: Cand.med. Theresa Mariero Olavsveengen (November 2009)

Theresa Olasveengen 5x7

Disputas: Cand.med. Theresa Mariero Olavsveengen ved Fakultetsdivisjon Ullevål universitetssykehus vil forsvare sin avhandling for graden ph.d. (philosophiae doctor) "Factors impacting on quality of prehospital advanced cardiac life support"
Tid og sted: 3. nov. 2009 10:15, Auditoriet i Kreftsenteret, Ullevål, Kirkeveien 166, Oslo


Disputas: Cand.med. Morten Pytte (November 2009)

Morten Pytte 5x7

Disputas: Cand.med. Morten Pytte ved Fakultetsdivisjon Ullevål universitetssykehus vil forsvare sin avhandling for graden ph.d. (philosophiae doctor)
"Cardiopulmonary resuscitation – guideline recommendation meet clinical practice" Tid og sted: 27. nov. 2009 10:15, Auditoriet i Kreftsenteret, Oslo universitetssykehus Ullevål, Kirkeveien 166


Disputas: Cand.med. Silje Ødegaard (October 2009)

Silje Ødegaar 5x7

Disputas: Cand.med. Silje Ødegaard ved Fakultetsdivisjon Ullevål universitetssykehus vil forsvare sin avhandling for graden ph.d. (philosophiae doctor)
"Searching for factors contributing to substandard quality of cardiopulmonary resuscitation in out-of-hospital cardiac arrest"
Tid og sted: 20. okt. 2009 10:15, Rødt Auditorium, Oslo universitetssykehus Ullevål, Kirkeveien 166


Disputas: Cand.med. Karl Esten Nakken (June 2009)

Disputas: Cand.med. Karl Esten Nakken ved Fakultetsdivisjon Ullevål universitetssykehus vil forsvare sin avhandling for graden ph.d. (philosophiae doctor)
"ABCB4 dysfunction and biliary disease”
Tid og sted: 12. jun. 2009 10:15, Store Auditorium, Oslo universitetssykehus, Ullevål, Kirkeveien 166


Disputas: MSc Santiago Zalvidea (April 2009)

Disputas: MSc Santiago Zalvidea
UUS (Cotutelle-avtale: Disputas i Montpellier, Frankrike)
"Role of angiotensin-converting enzyme inhibition on electrical and contractile properties of cardiomyocytes from failing heart in mice"


Careers: open position as PhD student

Hjerte (utdrag)

A PhD student position is available at Institute for Experimental Medical Research. The project is entitled: «Outrunning the wild at heart. Exercise training as anti-arrhythmic therapy in heart failure»
Read more...
- Stillingsannonse
- PhD prosjekt om trening og hjertestans: 3-årig stipend med mulighet for umiddelbar tiltredelse


Latest publication (March 2011)

The Journal of Physiology; Volume 589, Issue 6, pages 1443–1454, March 2011

Ida G. Lunde, Siobhan L. Anton, Jo C. Bruusgaard, Zaheer A. Rana, Stian Ellefsen, Kristian Gundersen

Hypoxia inducible factor 1α links fast-patterned muscle activity and fast muscle phenotype in rats

The Journal of Physiology, 2012;589:1443–1454.


Latest publication (February 2011)

Cell Physiology (March 2011)

Pimthanya Wanichawan, William E. Louch, Kristin H. Hortemo, Bjørg Austbø, Per Kristian Lunde, John D. Scott, Ole M. Sejersted, and Cathrine R. Carlson

Full length cardiac Na+-Ca2+ exchanger (NCX1) protein is not phosphorylated by protein kinase A (PKA)

American Journal of Physiology - Cell Physiology, 2011;300:C989-C997.


ESC Working Group on Cardiac Cellular Electrophysiology

35th Meeting of the European Working Group on Cardiac Cellular Electrophysiology

The 35th Meeting of the European Working Group on Cardiac Cellular Electrophysiology takes place in Oslo on September 17-19, 2011.
More information: www.ewgcce2011.no


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The Application of Organelle Proteomics to Heart Failure (February 2011) Husberg

Giulio Agnetti, Cathrine Husberg, Jennifer E. Van Eyk

Divide and Conquer: The Application of Organelle Proteomics to Heart Failure

Circulation Research, 2012;108:512-526


Latest publication (April 2011)

Journal of Applied Physiology , April 2011, 110 (4)

Ida Gjervold Lunde, Heidi Kvaløy, Bjørg Austbø, Geir Christensen, and Cathrine R. Carlson

Angiotensin II and norepinephrine activate specific calcineurin-dependent NFAT transcription factor isoforsm in cardiomyocytes

Journal of Applied Physiology, 2011;110:1278-1289
Accepted for publication: April 6, 2011
doi:10.1152/japplphysiol.01383.2010


Center for Cardiac Research (CECARE)

CECARE initiativ:

The groups headed by Professor Ole M. Sejersted and Professor Geir Christensen are currently involved in an application to the Norwegian Research Council for status as Center of Excellence. In case of such funding a Center for Cardiac Research (CECARE) will be formed. This center will also comprise members from the groups headed by Professors Otto A. Smiseth and Lars Gullestad (OUH Rikshopitalet), Finn Olav Levy (Dept of Pharmacology, UiO) and Torbjørn Omland (AHUS).

CECARE will focus on mechanisms for transition from risk factors to established heart failure with a broad translational approach.

Methods:
- Laboratory methods
- Animal models
- In vitro models
- Systems biology
- Clinical methods

Please read: List of Methods avilable at Center for Cardiac Research (CECARE)

Members:
Otto Smiseth = OS
Torbjørn Omland =TO
Geir Christensen = GC
Ole Sejersted = OMS
Lars Gullestad = LG
Finn Olav Levy =FOL


Latest publications (April 2011)

PLOS ONE (LOGO)

Anne Waehre, Bente Halvorsen, Arne Yndestad, Cathrine Husberg, Ivar Sjaastad, Ståle Nygård, Christen P. Dahl, M. Shakil Ahmed, Alexandra V. Finsen, Henrik Reims, William E. Louch, Denise Hilfiker-Kleiner, Leif E. Vinge, Borghild Roald, Håvard Attramadal, Martin Lipp, Lars Gullestad, Pål Aukrust, and Geir Christensen.

Lack of Chemokine Signaling through CXCR5 Causes Increased Mortality, Ventricular Dilatation and Deranged Matrix during Cardiac Pressure Overload.

PLoS ONE 6(4): e18668
Accepted for publication: April 18, 2011
doi:10.1371/journal.pone.0018668


Disputas 8. jun. 2011

Mathis Frøshaug Stokke 7x10

Cand.med. Mathis Korseberg Stokke
ved Institutt for klinisk medisin, Hjerte-, lunge- og karklinikken vil forsvare sin avhandling for graden ph.d. (philosophiae doctor)

"SERCA2-RyR2 interplay at the heart of Ca2+ wave development. Experimental studies on mechanisms underlying triggered arrhythmias."

Disputas 8. jun. 2011 13:15, Auditoriet i Kreftsenteret, Oslo universitetssykehus HF, Ullevål, Kirkeveien 166, Oslo

Prøveforelesning 8. jun. 2011 10:15 (Auditoriet i Kreftsenteret, Oslo universitetssykehus HF, Ullevål, Kirkeveien 166, Oslo) -
"Electophysiological basis for ventricular arrhythmias"

Mathis Frøshaug Stokke 7x10


Doctoral Thesis: 10th of June, 2011

Johannes L. Bjørnstad 5x7

Johannes Lagethon Bjørnstad, M.D. has defended his thesis for the degree of dr. philos. (doctor philosophiae):

"The TGF-β/SMAD signalling system and extracellular matrix changes in myocardial remodelling and reverse remodelling following correction of pressure overload "

Trial lecture "Nåværende og framtidige behandling av aortklaffesykdom"

Trial lecture: June 10, 2011, 10.15
Dissertation: June 10, 2011, 13.15

Venue: Gamle festsal, Urbygningen, Karl Johans gate 47, Oslo

Supervisor: Professor Theis Tønnessen


9th Annual CHFR Symposium

9th Annual CHFR Symposium

September 15-16, 2011 at Holmenkollen Park Hotel Rica

The meeting will be part of the official celebration of the 200th anniversary of the University of Oslo and is arranged back-to-back with the 35th Annual Meeting of the ESC Working Group on Cardiac Cellular Electrophysiology

Abstract deadline: June 6, 2011
Registration deadline: August 5, 2011

More information: Center for Heart Failure Research


Latest publication (June 2011)

Journal of Molecular and Cellular Cardiology, volume 51 2011

William E. Louch, Katherine A. Sheehan, Beata M. Wolska

Methods in cardiomyocyte isolation, culture, and gene transfer

Journal of Molecular and Cellular Cardiology, 2011;51:288-298


Scientist of the Month

Ole Sejersted, August Scientist of the Month 2011

Head of Institute Professor Ole M. Sejersted is selected as Scientist of the Month by the South-Eastern Norway Regional Health Authority.

Read the interview with the August Scientist of the Month at
Helse Sør-Øst, Aktuelt


MR scanner - ongoing research

Contrast-enhanced  imaging of myocardium for identification of infarct (Fig. 2)

Ongoing research utilise:

- Cine cardiac imaging for anatomy, ejection fraction, ventricle size and wall thicknesses (Click to see a video)

- Contrast-enhanced imaging of myocardium for identification of infarct.

- Quantification of myocardium viability by high spatial and temporal resolution phase contrast imaging.

- Ultra high resolution anatomical imaging of fixed tissue (~ 25 microns).

- In vivo characterization of prostate growth and response to treatment of prostate cancer.

- In vivo characterization of brain tumor growth.

- 31P MRS of skeletal muscle in rats.

- 1H and 31P MRS of mouse heart.

- White matter fiber characterization using DTI (diffusion tensor imaging) to measure experimental alterations in axons and myelin in the brain and spinal cord.

Click for more information about Oslo Preclinical MR Core Facility and contact addresses.


Doctoral theses; Institute for Experimental Medical Research; UUS 1957-2009

Please read: Doctoral theses; Institute for Experimental Medical Research; UUS 1957-2009


Latest publication (May 2011)

Resuscitation, Volume 82, Issue 9 , Pages 1186-1193, September 2011.

Øystein Tømte, Geir Øystein Andersen, Dag Jacobsen, Tomas Drægni, Bjørn Auestad, Kjetil Sunde Hide

Strong and weak aspects of an established post-resuscitation treatment protocol—A five-year observational study.

Resuscitation, 2011;82:1186-1193


Doctoral Thesis: 23rd September 2011

Haakon Kiil Grøgard 300dpi7x5

Cand.med. Haakon Kiil Grøgaard has defended his thesis for the degree of dr.philos. (doctor philosophiae):

Progenitor cells, growth factors and inflammation in acute myocardial infarction.

Trial lecture: Koronar CT angiografi i utredningen av mistenkt kransarteriesykdom

Trial lecture: Sept. 23, 2011, 10:15 am
Dissertation: Sept. 23, 2011, 14:15 pm

Venue: Rødt Auditorium, Laboratoriebygget, Oslo universitetssykehus HF, Ullevål, Kirkeveien 166

Veileder: Professor Arnfinn Ilebekk


Fredrik Kiil 90 Year Anniversary

20110818 Fredrik Kiil 2011

Professor emeritus Fredrik Kiil, M.D., Ph.D. (29. september 1921-) . Head of Institute for Experimental Medical Research (IEMR) 1962 - 1991.

Fredrik Kiil was borne in Narvik, Norway and graduated from University of Oslo in 1948. Ph.D. Oslo University 1958. He became specialist in internal medicine in 1961, and served as Head of IEMR 1961 - 1991. Fredrik Kiil was visiting professor at University of Texas Southwestern Medical School, Dallas, U.S.A., 1961.

Fredrik Kiil pioneered the development of the artificial kidney and his version, first produced at the IEMR, found use in many countries throughout the world. His extensive medical research activity covers ureteral, renal and cardiovascular physiology.

Awards: Anders Jahre's Prize for Medicine 1980. National Kidney Foundation Dialysis Pioneering Award 1982 (U.S.A.). Knight of the Order of St. Olav 1991

Read more about Fredrik Kiil in "Store norske leksikon"
Click here to see an image of the Kiil artificial kidney


The Kiil artificial kidney

The Kiil artificial kidney

Fredrik Kiil, M.D. pioneered the development of an artificial kidney at the IEMR between 1957 and 1961. His ambition was to develop an artificial kidney having high hemodynamic conductivity, high capacity for removing urea and creatinine from the patient as well as having the ability to rid the patient of desired quantities of water. An overriding goal was to make the artificial kidney simple, inexpensive and reusable.

Working together with engineer Bjørn Amundsen at the IEMR, several models were tried out. The final product consisted of a 4-layered dialysis unit incorporating cuprophane membranes totalling 2 square meters. The kidney quickly attracted international attention and was soon used in many countries all over the world.

Image of the Kiil artificial kidney


Brief history

The IEMR was established in 1951 at the initiative of Carl B. Semb, Professor of Surgery, and made possible through a grant from shipowner Anders Jahre. Their idea was to create an environment that promoted research in collaboration with the clinical departments at Oslo University Hospital - Ullevål. The links to the hospital's Department of Surgery have always been close.

Professor Fredrik Kiil served as Head of Institute from 1961 to 1991. He developed the first extensively used artificial kidney and established renal physiology as the major research area at the Institute. Through several years professor Morten Harboe built up a strong group in immunology and leprosy research. This field was abandoned when Harboe moved his group to the National Hospital in 1983. Kiil also initiated research in cardiac and vascular physiology, and professor Arnfinn Ilebekk has headed this research for many years. Morten G. Ræder joined the IEMR in 1982 following his appointment as Professor of Surgical Pathophysiology. He has since supervised his own group investigating mechanisms biliary and pancreatic secretion. Professor Ræder retired at the age of 70 in January 2009. Professor of Anesthesia, Petter A. Steen, has supervised research activity relating to heart and lung resuscitation since 1982.

Ole M. Sejersted was appointed Professor and Head of Institute in 1991. Since then, renal physiology ceased to be an area of investigation, and the focus shifted to cardiovascular research in addition to continued activity in biliary and pancreatic research. Cellular and molecular biological techniques have been introduced. Geir Christensen MD, Ph.D. was appointed Director of Research in 1998 and professor in 2003.

The Institute now has four research groups headed by Christensen, Sejersted, Ilebekk and Steen. Other investigators from the hospital also use facilities at the Institute for their research. Thus, professor Jarle Vaage at Ullevål has had a laboratory at the Institute at his disposal for some years


Prize winners of the Poster Session

COVER 9th CHFR

Posters which got first prize from our Institute during the 9th Annual CHFR Symposium held last Sept. 15-16, 2011 at the Hollmenkollen Park Hotel Rica, Oslo:

William E. Louch, et al. with poster entitled: "P27 Causes and consequences of cardiomyocyte Na+ loading following SERCA2 knockout"
Anton Baysa, et al. with poster entitled: "The role of p66Shc adaptor protein in postinfarction cardiac remodeling"
Trine Baur Opstad, et al. with poster entitled: "P44 The influence of tissue factor and tissue factor pathway inhibitor polymorphisms on thrombin generation in stable CAD patients"

Other posters from our Institute which were ranked top 3 in their sessions were posters presented by: Thomas Schwartz, Anne Wæhre, Jonas Skogestad and Anett Heilebø Ottesen. Congratulations!

More information: Center for Heart Failure Research


Latest publication (October 2011)

Heart Failure Reviews oct 2011

Tommy Rehn, Morten Munkvik, Per Kristian Lunde, Ivar Sjaastad, Ole M. Sejersted.

Intrinsic skeletal muscle alterations in chronic heart failure patients: a disease-specific myopathy or a result of deconditioning?

Heart Failure Reviews, 2012;17:421-436.


Latest publications (September 2011)

The Journal of physiology Volume 589, Issue 21, November 2011

Cecilie Sjåland, Per Kristian Lunde, Fredrik Swift, Morten Munkvik, Madelene Ericsson, Marianne Lunde, Sigurd Boye, Geir Christensen, Øyvind Ellingsen, Ole M. Sejersted and Kristin B. Andersson

Slowed Relaxation and Preserved Maximal Force in Soleus Muscles of Mice with Targeted Disruption of the Serca2 gene in Skeletal Muscle.

The Journal of physiology, 2011;589:6139-6155.


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Acta_Anaesthesiologica_Scandinavica_Cover

Andres Neset, Tonje S. Birkenes, T. Furunes, He. Myklebust, R. J. Mykletun, Silje Ødegaard, Theresa Mariero Olasveengen and Jo Kramer-Johansen

A randomized trial on elderly laypersons’ CPR performance in a realistic cardiac arrest simulation.

Acta Anaesthesiologica Scandinavica, 2012;56:124-131.


60th Year Anniversary

60 year anniversary

The Institute for Experimental Medical Research (IEMR) was established in 1951 at the initiative of Carl B. Semb, Professor of Surgery, and made possible through a grant from shipowner Anders Jahre. Since then more than 120 Doctoral theses have been published at the Institute.

We proudly present an overview of Candidates and Doctoral Theses:

- Survey of Doctoral theses and Candidates, Institute for Experimental Medical Research, OUS 2009-2011.

- Survey of Doctoral theses and Candidates, Institute for Experimental Medical Research, UUS 1957-2009.

To read more about IEMR click here .


Vacant position

Person no photo availiable 1.5

Vacant Professorship or Associate Professorship
at Institute for Experimental Medical Research.

See "forskning.no"


Latest publication (January 2012)

Cardiovascular Research December 1 2011

Johannes L. Bjørnstad, Biljana Skrbic, Henriette S. Marstein, Almira Hasic, Ivar Sjaastad, William E. Louch, Geir Florholmen, Geir Christensen, and Theis Tønnessen

Inhibition of SMAD2 phosphorylation preserves cardiac function during pressure overload

Cardiovascular Research,2012:93:100–110


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