Archive

Doctoral Thesis: 17th of February 2012

Øystein Tømte 5x7

Øystein Tømte, M.D. has defended his thesis for the degree of Ph.D. (philosophiae doctor):

"Out-of-hospital cardiac arrest - improving cardiopulmonary resuscitation and post resuscitation care"

Trial lecture: "The Experimental Basis for Therapeutic Hypothermia after Brain Ischemia: How Cold, How Long and How Late Can You Start."

Trial lecture: 17. feb. 2012, 10:15
Dissertation: 17. feb. 2012, 13:15

His thesis work was carried out at the Institute for Experimental Medical Research in collaboration with the Department of Anaesthesiology, Oslo University Hospital.

Venue: Rødt auditorium, Laboratoriebygget, Oslo University Hospital, Ullevaal, Kirkeveien 166

Supervisors: Professor Kjetil Sunde, MD, PhD and Lars Wik, MD, PhD


Latest publication (February 2012)

PNAS March 6, 2012 vol. 109 no. 10

Fredrik Swift, Clara Franzini-Armstrong, Leiv Øyehaug, Ulla Helene Enger, Kristin Brevik Andersson, Geir Christensen, Ole M. Sejersted, and William E. Louch

Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling following Serca2 knockout

Proc.Natl.Acad.Sci.U.S.A., 2012;109:3997-4001.

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Magnetic Resonance in Medicine Vol 67 Issue 4

Emil K. S. Espe, Jan Magnus Aronsen, Biljana Skrbic, Vidar Magne Skulberg, Jürgen E. Schneider, Ole M. Sejersted, Lili Zhang, Ivar Sjaastad

Improved MR phase contrast velocimetry utilizing a novel nine-point balanced motion encoding scheme with increased robustness to eddy current effects

Magnetic Resonance in Medicine
Article first published online: 5 March 2012, doi: 10.1002/mrm.24226


Latest publications (March 2012)

Resuscitation March 2012

Theresa M. Olasveengen, Lars Wik, Kjetil Sunde, Petter A. Steen

Outcome when adrenaline (epinephrine) was actually given vs. not given – posthoc analysis of a randomized clinical trial

Resuscitation, 2012:83:327–332.


Doctoral Thesis: 12th of April 2012

Cecilie Sjåland 5x7

M.Sc. Cecilie Sjåland has defended her thesis for the degree of Ph.D. (philosophiae doctor):

Physiological consequences of targeted loss of SERCA2 in heart and skeletal muscle

Trial lecture:The role of the 3Na+/2K+ pump and other P-type transport ATPases in health and disease.

Trial lecture: 12. apr. 2012, 10:15 am
Dissertation: 12. apr. 2012, 12:15 am

Venue: Store auditorium, Oslo universitetssykehus HF, Ullevål, Kirkeveien 166, Oslo
Supervisor: Professor Ole M. Sejersted,
Institute of Clinical Medicine, University of Oslo


Abstracts

  • All abstracts must be submitted electronically as a Word document through www.iemf.no.
  • The abstract must be written in English and must not exceed 300 words in addition to the title and author names.
  • Figures are accepted, but counts as 100 words. Figure files must be submitted separately as EPS or high resolution TIFF files (300 dpi or higher) by e-mail to fredrik.swift@medisin.uio.no
  • The abstract text must contain title, authors and affiliations. Use Arial 10pt fonts.
  • All authors should be listed by their last name and initials. The name of the presenting author should be indicated using bold font type. Affiliations should be listed using numbers in superscript:

Author1 A1, Author2 B2, Author3 C1,2
1Department 1
2Department 2


Doctoral Thesis: 10th of May 2012

Ida Gjervold Lunde 5x7

M.Sc. Ida Gjervold Lunde has defended her thesis for the degree of Ph.D. (philosophiae doctor):

"Molecular mechanisms of heart failure; Nuclear Factor of Activated T-cell (NFAT) signaling in myocardial hypertrophy and dysfunction"

Trial lecture: "Strengths and limitations in use of animal models and model organisms for human heart failure research."

Trial lecture: May 10, 2012, 10:15 am
Dissertation: May 10, 2012, 13:15 am

Venue: Green Auditorium, Building 25 (Lab bldg.), Oslo University Hospital, Ullevål, Kirkeveien 166

Supervisors: Cathrine R. Carlson and Professor Geir Christensen,
Institute of Clinical Medicine, University of Oslo


Latest publication (April 2012)

Biophysical Journal vol 102

Liren, Li, William E. Louch, Steven A Niederer, Jan M. Aronsen, Geir Christensen, Ole M. Sejersted, and Nicolas P. Smith

Sodium Accumulation in SERCA Knockout-Induced Heart Failure.

Biophysical Journal, 2012;102:2039-2049


Latest publication (May 2012)

Journal of Applied Physiology, vol 112, number 8

Anne Wæhre, Maria Vistnes, Ivar Sjaastad, Ståle Nygård, Cathrine Husberg, Ida Gjervold Lunde, Pål Aukrust, Arne Yndestad, Leif E. Vinge, Dina Behmen, Christian Neukamm, Henrik Brun, Erik Thaulow and Geir Christensen

Chemokines regulate small leucine-rich proteoglycans in the extracellular matrix of the pressure-overloaded right ventricle

The Journal of Applied Physiology, 2012;112:1372-1382.


Doctoral Thesis: 1st of June, 2012

Helge Røsjø 5x7

Cand.med. Helge Rørvik Røsjø has defended his thesis for the degree of Ph.D. (philosophiae doctor):

The granin protein family in cardiac disease.

Trial lecture: The heart as an endocrine organ.

Trial lecture: 1. June, 10:15 am
Dissertation: 1. June, 13:15 am

Venue: Store auditorium, Akershus universitetssykehus, Lørenskog

Supervisor: Professor Torbjørn Omland, Institute of Clinical Medicine, University of Oslo


Doctoral Thesis: 4th of June, 2012

Anne Wæhre 5x7

Cand.med. Anne Wæhre has defended her thesis for the degree of Ph.D. (philosophiae doctor):

Chemokines in cardiac remodelling and heart failure, and their role in regulation of small leucine-rich proteoglycans in the extracellular matrix.

Trial lecture: Kardiomyopati hos barn – årsaker, utredning og behandling.

Trial lecture: 4th of June, 10:15 am
Dissertation: 4th of June, 13:15 am

Venue: Auditorium 1 (grønt), Rikshospitalet, Sognsvannsveien 20, Oslo

Supervisor: Professor Geir Christensen, Institute of Clinical Medicine, University of Oslo


Latest publications (June 2012)

American Journal of Physiology Heart Circulatory Physiology

William E. Louch, Peter Vangheluwe, Virginie Bito, Luc Raeymaekers, Frank Wuytack, Karin R. Sipido

Phospholamban ablation in hearts expressing the high affinity SERCA2b isoform normalizes global Ca2+ homeostasis but not Ca2+ -dependent hypertrophic signaling

American Journal of Physiology - Heart and Circulatory Physiology,2012;302,H2574-2582.


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PLOS ONE (LOGO)

Travis L. Dutka, Esther Verburg, Noni Larkins, Kristin H. Hortemo, Per K. Lunde, Ole M. Sejersted, Graham D. Lamb

ROS-Mediated decline in maximum Ca2+ -activated force in rat skeletal muscle fibers following in vitro and in vivo stimulation

Plos One, 2012;7:e35226
Accepted for publication: March 13, 2012


Latest publication (July 2012)

Journal of Physiology

Sander Land, Steven A. Niederer, Jan Magnus Aronsen, Emil K. S. Espe, Lili Zhang, William E. Louch, Ivar Sjaastad, Ole M. Sejersted, Nicolas P. Smith;

An analysis of deformation dependent electromechanical coupling in the mouse heart

Journal of Physiology, 2012;590:4553-4569


Latest publication (November 2011)

PLOS ONE (LOGO)

Alexander V. Finsen, Ida G. Lunde, Ivar Sjaastad, Even K. Østli, Marianne Lyngra, Hilde O. Jarstadmarken, Almira Hasic, Ståle Nygård, Sarah A. Wilcox-Adelman, Paul F. Goetinck, Torstein Lyberg, Biljana Skrbic, Geir Florholmen, Theis Tønnessen, William E. Louch, Srdjan Djurovic, Cathrine R. Carlson, Geir Christensen

Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway

Plos One, 2011;6:e28302.


Latest publication (July 2011)

AJP Lung Cellular Molecular Physiology

Karl-Otto Larsen, Arne Yndestad, Ivar Sjaastad, Else Marit Løberg, Ingeborg Løstegaard Goverud, Bente Halvorsen, Jing Jia, Arne K. Andreassen, Cathrine Husberg, Sofia Jonasson, Martin Lipp, Geir Christensen, Pål Aukrust and Ole Henning Skjønsberg

Lack of CCR7 induces pulmonary hypertension involving perivascular leukocyte infiltration and inflammation

American Journal of Physiology Lung Cellular Molecular Physiology, 2011;301:L50-L59


Latest publication (August 2012)

Experimental Lung Research

Fadila Telarevic Cero, Vigdis Hillestad, Else Marit Løberg, Geir Christensen, Karl-Otto Larsen, and Ole Henning Skjønsberg

IL-18 and IL-12 synergy induces matrix degrading enzymes in the lung

Experimental Lung Research
Accepted July 26, 2012
DOI: 10.3109/01902148.2012.716903


Latest publications (September 2012)

Cardiology

Peter Majak, Johannes L. Bjørnstad, Bjørn Braathen, Ida G. Lunde, Trygve Husebye, Geir Christensen, Theis Tønnessen

Endothelin-1 in the human myocardium and circulating plasma: Evaluation before, during and after correction of aortic stenosis with aortic valve replacement

Cardiology
Accepted after revision: May 20, 2012
Published online: August 17, 2012
DOI: 10.1159/000339756


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Cardiovascular Research

Fredrik Swift and Geir Christensen

Calcium release units in heart failure: that's about the size of it

Cardiovasc. Res, 2012;95:397-398


Latest publication (October 2012)

Physiology

William E. Louch, Mathis K. Stokke, Ivar Sjaastad, Geir Christensen, and Ole M. Sejersted

No rest for the weary: Diastolic calcium homeostasis in the normal and failing myocardium

Physiology, 2012;27:308-323.

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Fredrik Swift received the Oslo University Hospital's price for Outstanding Research Article

Fredrik Swift, 2013

Five other research groups at Oslo University Hospital also got recognition. This price is awarded by Oslo University Hospital every 6 months for high quality articles that shows important findings in the short and long term. Every winner receives 50000 kroner in support of their research.

The article of Fredrik Swift which received the award:

Fredrik Swift, Clara Franzini-Armstrong, Leiv Øyehaug, Ulla Helene Enger, Kristin Brevik Andersson, Geir Christensen, Ole M. Sejersted, and William E. Louch

Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling following Serca2 knockout

Proc.Natl.Acad.Sci.U.S.A., 2012;109:3997-4001.

Click and read


Alexandra Finsen and Ida G. Lunde receives Oslo University Hospital's price on Outstanding Research Article for 2nd half-year of 2011

Prisvinnere Ida og Alexandra

Finsen AV, Lunde IG, Sjaastad I, Østli EK, Lyngra M, et al.

Syndecan-4 Is Essential for Development of Concentric Myocardial Hypertrophy via Stretch-Induced Activation of the Calcineurin-NFAT Pathway.

PLoS ONE 6(12): e28302. doi:10.1371/journal.pone.0028302
OPEN ACCESS Freely available online

Click and read

In order to stimulate excellent research and draw attention to the hospital's extensive research activity, Oslo University Hospital reward outstanding publications regularly. Every half-year, six of the very best papers authored by OUS-scientists are selected.


Core Facility Confocal Microscopy

Our institute is one of the nodes in a core facility for confocal microscopy financed by Helse Sør-Øst. The two other nodes are located at Montebello and Gaustad.

The Confocal Core Facility Confocal Microscopy Ullevål holds three confocal microscopes and two whole cell fluorescence setups as well as software for image enhancement.
More information about core facilities at OUS can be found at http://ous-research.no/core-ous/

Equipment:

Zeiss LSM 710 / Axio Observer
Inverted confocal microscope used for studying protein localization and colocalization using traditional antibody labelling as well as Duolink. The microscope is also set up for FRET.
Laser lines: 458-488-514-543-633 nm.

Zeiss Live 7 / Axio Observer
Inverted confocal microscope used for studying Ca2+ dynamics in live cells. The Live 7 provides high speed scanning and gives acquisition rates of 1000 images of 512 x 512 pixels in less than 10 seconds. The microscope is set up with a perfusion system (37°C), patch clamp equipment (Axon Axopatch 200B) and field stimulation. Flash photolysis equipment is a also available.
Laser lines: 488-532 nm.

Zeiss LSM 510 / Axiovert 100
Inverted confocal microscope used for studying Ca2+ dynamics in live cells and protein localisation/colocalization. Also equiped with perfusion system (37°C), electrophysiology (Axon Axoclamp 2B) and field stimulation.
Laser lines: 488-543-633 nm.

Zeiss Axiovert 200 / Cairn Optoscan
Inverted widefield microscope used for studying Ca2+ dynamics in live cells. Whole cell fluorescence (for example Fluo-4) can be measured using fluorescence system from Cairn Research (Optosource/Optoscan/1 detection channel). Also equiped with perfusion system (37°C), electrophysiology (Axon Axoclamp 2B) and field stimulation.

Zeiss Axio Observer / PTI
Inverted widefield microscope used for studying Ca2+ dynamics in live cells. Whole cell ratiometric fluorescence (for example Fluo-4, Fura-2, SBFI) can be measured using fluorescence system from Photon Technology International (RatioMaster/2 detection channels). Also equiped with perfusion system (37°C), electrophysiology (Axon Axoclamp 2A) and field stimulation.

Huygens deconvolution software from Scientific Volume Imaging
We hold a licence for use of deconvolution software from SVI which improves image quality by reversing optical distortion in the image.


Doctoral Thesis: 26th of November, 2012

Maria Vistnes 5x7

Cand. med. Maria Vistnes has defended her thesis for the degree of Ph.D. (philosophiae doctor)

Cytokines and extracellular matrix in heart failure

Trial lecture: Immune-mediated cellular adaptations in heart failure: potential therapeutic targets

Trial lecture: 26th of November, 9:00 am
Dissertation: 26th of November, 11:00 am

Venue: Auditorium, Kreftsenteret, Building 11, Oslo University Hospital Ullevål

Supervisor: Professor Geir Christensen, Institute of Clinical Medicine, University of Oslo


Theresa Olasveengen received the Max Harry Weil Award 2012 during the American Heart Association Conference in L.A.

Theresa Olasveengen 5x7

The Max Harry Weil Award honors the memory of Max Harry Weil, MD, PhD, considered the “father of critical care medicine” and a pioneer in 3CPR science. This award was established in 2012 and acknowledges the accomplishments of young investigators and to encourage investigators to continue their research in biomedical sciences relevant to the mission and scope of the 3CPR council.

Theresa Olasveengen received the award during the annual council dinner at AHA Scientific Sessions in Los Angeles, USA last November 6, 2012.


Latest publication (November 2012)

Journal of Molecular and Cellular Cardiology

Kate M. Herum, Ida G. Lunde, Biljana Skrbic, Geir Florholmen, Dina Behmen, Ivar Sjaastad, Cathrine R. Carlson, Maria F. Gomez, and Geir Christensen

Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress

Journal of Molecular and Cellular Cardiology.
Accepted: 22. november, 2012
Doi: 10.1016/j.yjmcc.2012.11.006. [Epub ahead of print]


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