Archive

Latest publication (December 2012)

Matrix Biology

Biljana Skrbic, Johannes L. Bjørnstad, Henriette S. Marstein, Cathrine R. Carlson, Ivar Sjaastad, Ståle Nygård, Sigrid Bjørnstad, Geir Christensen, Theis Tønnessen.

Differential regulation of extracellular matrix constituents in myocardial remodeling with and without heart failure following pressure overload

Matrix Biology, 2012.
doi: 10.1016/j.matbio.2012.11.011. [Epub ahead of print]


Location

Core Facility Node leader: Ivar Sjaastad,
e-mail: ivar.sjaastad@medisin.uio.no
phone: +47 23 01 67 97

Oslo University Hospital, Ullevål, Building 25,
Kirkeveien 166, NO-0407 Oslo, Norway


Safety precautions in MR environments

WARNING: Strong magnetic fields may be hazardous to heart pacemakers and matallic implants. Iron and steel materials must not be taken into the area. Serious injury or property damage may result.

Magnetic fields can destroy credit cards and key cards.


Biosafety in laboratory animal facility

biological hazard

Animals from other clean facilities might be transfered to the lab, but will then be concidered as contaminated and not brought out of the Section.

Course in Laboratory Animal Science for Researchers (FELASA C) from the Norwegian School of Veterinary Science, or similar institutions, is mandatory.

Be aware of possible allergic reactions!

Contact:
New research projects using MRI can be started by scheduling an appointment to discuss the project with Professor Ivar Sjaastad . For technical questions please contact Head Engineer Lili Zhang, PhD

Equipment and technical specifications:
Click to download document



Click for more information about our METHODS or our ONGOING RESEARCH.


Funding and Fees

Strong Magnetic Field DANGER

The MR core facility is supported by grants from Helse sør-øst.

For academic users the user fee will be:

  • Renting the equipment kr. 150,- pr hour
  • Using the staff kr. 300,- pr hour (training, acquisition, analysis)

For non-academic users the user fee will be:

  • Renting the equipment kr. 800,- pr hour
  • Using the staff kr. 450,- pr hour (training, acquisition, analysis)

All users must cover damage inflicted to the instruments or software.


Latest publication (January 2013)

Interface Focus

Sander Land, Steven A. Niederer, William E. Louch, Ole M. Sejersted, Nicolas P. Smith

Integrating multi-scale data to create a virtual physiological mouse heart.

Interface Focus, 2013.


Latest publication (February 2013)

Journal of Molecular and Cellular Cardiology

William E. Louch, Johan Hake, Halvor K. Mørk, Karina K. Hougen, Biljana Skrbic, Daniel Ursu, Theis Tønnessen, Ivar Sjaastad, Ole M. Sejersted

Slow Ca2+ sparks de-synchronize Ca2+ release in failing cardiomyocytes: evidence for altered configuration of Ca2+ release units?

Journal of Molecular and Cellular Cardiology
Accepted: January 2013
Doi: 10.1016/j.yjmcc.2013.01.014. [Epub ahead of print]


Latest publication (March 2013)

FEBS J

Mari E. Strand, Kate M. Herum, Zaheer A. Rana, Biljana Skrbic, Erik T. Askevold, Christen P. Dahl, Maria Vistnes, Almira Hasic, Heidi Kvaløy, Ivar Sjaastad, Cathrine R. Carlson, Theis Tønnessen, Lars Gullestad, Geir Christensen, and Ida G. Lunde

Innate immune signalling induces expression and shedding of the heparan sulphate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart

FEBS Journal
Accepted for publication: 28 January 2013
Doi:10.1111/febs.12161


Latest publication (April 2013)

Cardiovascular Research

Mathis K. Stokke, Nils Tovsrud, William E. Louch, Leiv Øyehaug, Karina Hougen, Ole M. Sejersted, Fredrik Swift, Ivar Sjaastad

ICaL inhibition prevents arrhythmogenic Ca2+ waves caused by abnormal Ca2+ sensitivity of RyR or SR Ca2+ accumulation

Cardiovascular Research. 2013;98:315-325
Accepted 11 February 2013


Kate M. Herum received the Oslo University Hospital's price for Outstanding Research Article

Kate Herum, forskningspriser-ous-april 2013

Awarded article:
Herum KM, Lunde IG, Skrbic B, Florholmen G, Behmen D, Sjaastad I, Carlson CR, Gomez MF, Christensen G.
Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress.
Journal of Molecular and Cellular Cardiology, 2013 Jan;54:73-81.
Click and read

Five other research groups at Oslo University Hospital also got recognition. This price is awarded by Oslo University Hospital every 6 months for high quality articles that shows important findings in the short and long term. Click to read more


Latest publication (May 2013)

FEBS J

Kristin V. Engebretsen, Ida G. Lunde, Mari E. Strand, Anne Waehre, Ivar Sjaastad, Henriette Marstein, Biljana Skrbic, Christen P. Dahl, Erik T. Askevold, Geir Christensen, Johannes L. Bjornstad, Theis Tønnessen

Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and pro-inflammatory stimuli

FEBS J. 2013;280:2382-2398.
Accepted for publication: March 5, 2013


Award Winners, Heart Failure 2013

Young Investigator Awards
Young Investigator Awards

Winners and runners up of the Young Investigator Awards - Basic science: Ida Gjervold Lunde (2nd runner up)

"Experimental and clinical aortic stenosis; myocardial activation of the four pro-hypertrophic NFAT transcription factors is attenuated by relief of pressure overload"

Authors: IG Lunde, B Skrbic, T Tonnessen, H Kvaloy, UH Enger, I Sjaastad, G Christensen, CR Carlson, Oslo University Hospital; University of Oslo - Oslo - Norway,

Access the abstract here!

HEART FAILURE 2013, 25-28 May, Lisbon, Portugal
Click to meet all the Award Winners at Heart Failure 2013

Diplom Ida - Young Investigator Awards
Diploma


Heart Failure 2013, 25-28 May, Lisbon, Portugal

Young Investigator Awards  - Utdrag, IDA

Winners and runners up of the Young Investigator Awards - Basic science: Ida Gjervold Lunde

Click to read more!

"Experimental and clinical aortic stenosis; myocardial activation of the four pro-hypertrophic NFAT transcription factors is attenuated by relief of pressure overload"

Authors: IG Lunde, B Skrbic, T Tonnessen, H Kvaloy, UH Enger, I Sjaastad, G Christensen, CR Carlson,
Oslo University Hospital; University of Oslo - Oslo - Norway,

Access the abstract here!


Latest publication (June 2013)

Resuscitation

Eric Qvigstad, Jo Kramer-Johansen, Øystein Tømte, Tore Skålhegg, Øyvar Sørensen, Kjetil Sunde, Theresa M. Olasveengen

Clinical pilot study of different hand positions during manual chest compressions monitored with capnography

Resuscitation
Accepted for publication: March 9, 2013
Doi.org/10.1016


Latest publication (July 2013)

Annals of the Rheumatic Disease

Thomas Schwartz, Helga Sanner, Ola Gjesdal, Berit Flatø and Ivar Sjaastad

In juvenile dermatomyositis cardiac systolic dysfunction is present after long-term follow-up, and is predicted by sustained early skin activity

Annals of the Rheumatic Disease
Accepted for publication: June 29, 2013
doi: 10.1136/annrheumdis-2013-203279


Scientist of the Month July 2013

Geir Christensen 5x7

Professor MD Geir Christensen was chosen as the Scientist of the Month of July by the South-Eastern Norway Regional Health Authority.

Read the interview on this link


11th Annual CHFR Symposium on Heart Failure

11th Annual CHFR Symposium on Heart Failure

Holmenkollen Park Hotel Rica, September 19-20, 2013

The symposium arranged by Center for heart failure research is open to all clinical and basic researchers, and provides a unique meeting place for regional, national and international interaction.

All seminar attendees must register. There is no registration fee.
Registration before August 13, 2013.

Click here for more information and registration.
Click here to download program.


His Majesty the King’s gold medal 2013

Ida Gjervold Lunde 2013
Ida Gjervold Lunde tildeles H.M. Kongens gullmedalje 2013

Ida Gjervold Lunde, is awarded His Majesty the King's Gold Medal
The Gold Medal may be awarded to outstanding young researchers for work that is acknowledged to be a significant contribution to research literature in the relevant field.
She will be presented with the medal on the University of Oslo's annual celebration. Time and place: September 2nd at 2:00 p.m - 3:30 p.m, The University Aula, Karl Johans gate 47, Oslo
Click here for more information about the ceremony.
Read about His Majesty the King’s gold medal...
Read "Aktuelt fra KLINMED"

His Majesty The King grants PhD Ida Gjervold Lunde, recipient of His Majesty The King's Gold Medal.
Audience in The Royal House of Norway, 20.09.2013


Latest publication (August 2013)

Plos One

Kristin Halvorsen Hortemo, Morten Munkvik, Per Kristian Lunde and Ole M. Sejersted

Multiple causes of fatigue during shortening contractions in rat slow twitch skeletal muscle

Plos one, 2013; 8(8):e71700
Accepted for publication: August 16, 2013
doi:10.1371/journal.pone.0071700


Prize winners of the Poster Session

11th Annual CHFR Symposium on Heart Failure

Posters from our Institute which got first prize during the
11th Annual CHFR Symposium:

Ida Gjervold Lunde: Clinical and Experimental Aortic Stenosis; Attenuation of Activated Pro-Hypertrophic NFAT Transcription Factor Isoforms During Reverse Remodeling
Ravinea Manotheepan: Exercise training reduces Ca2+-calmodulin-dependent protein kinase type II dependent phosphorylation of the cardiac ryanodine receptor and Ca2+ leak from the sarcoplasmic reticulum in mice with mutant cardiac ryanodine receptor 2
Anett H. Ottesen: Secretoneurin is a Novel Endogenous CaMKIIδ inhibitor that Regulates Cardiomyocyte Calcium Handling and is Closely Associated with Mortality in Patients with Acute Heart Failure
Vigdis Hillestad: IL-18 neutralization during alveolar hypoxia improves left ventricular diastolic function and partly prevents right ventricular hypertrophy

Other posters from our Institute which were ranked top 3 in their sessions, were presented by: Kate M. Herum, Jonas Skogestad
Congratulations!

More information: Center for Heart Failure Research


Latest publication (September 2013)

Journal of Cardiovascular Magnetic Resonance (Espe)

Emil K.S. Espe, Jan Magnus Aronsen, Kristine Skårdal, Jürgen E. Schneider, Lili Zhang and Ivar Sjaastad

Novel insight into the detailed myocardial motion and deformation of the rodent heart using high-resolution phase contrast cardiovascular magnetic resonance

Journal of Cardiovascular Magnetic Resonance. 15:82
Accepted for publication: September 3, 2013
doi:10.1186/1532-429X-15-82

Click and read


Young Investigator Award, FEBS 2013

FEBS is the Federation of the Societies of Biochemistry and Molecular Biology

Kate Herum received the "Federation of the Societies of Biochemistry and Molecular Biology, Young Investigator Award" for the presentation: "Syndecan-4 promotes myocardial stiffness by regulating myofibroblast differentiation and extracellular matrix structure in response to pressure overload" at FEBS Advanced Lecture Course - Matrix Pathobiology, Signaling and Molecular Targets, Kos, 26 September - 1 October, 2013

The best 3 abstracts received the "FEBS-MPST2013 Young Investigator Award" at the end of the course.


Latest publication (October 2013)

Journal of Applied Physiology

Vigdis Hillestad, Frank Kramer, Stefan Golz, Andreas Knorr, Kristin B. Andersson and Geir Christensen

Long-term levosimendan treatment improves systolic function and myocardial relaxation in mice with cardiomyocyte-specific disruption of the SERCA2 gene

J. Appl. Physiol.
doi:10.1152/japplphysiol.01044.2012


Latest publication (October 2013)

Acta Anaesthesiol. Scand.

Andres Neset, Trond Nordseth, Jo Kramer-Johansen, Lars Wik and Theresa Olasveengen

Effects of adrenaline on rhythm transitions in out-of-hospital cardiac arrest

Acta Anaesthesiol. Scand.
doi: 10.1111/aas.12184


IEMR Annual Institute Seminar; Madrid 2013

Residencia de Estudiantes

The joint seminar between Institute for Experimental Medical Research and Instituto de Investigaciones Biomédicas "Alberto Sols" was held at Residencia de Estudiantes, one of the most prominent cultural centres in the city of Madrid. Situated in a meeting place open to creativity, intellectual and interdisciplinary dialogue, we discussed: Ion Channels, Diastolic Properties of the heart, Matrix Biology, and Protein - Protein interactions.
In additions we spent days of cultural and soscial activities.

Thank you very much to Carmen Valenzuela, Investigador Científico, for the coordination!


Latest publication (November 2013)

Journal of Applied Physiology 115 home_cover

Long-term levosimendan treatment improves systolic function and myocardial relaxation in mice with cardiomyocyte-specific disruption of the SERCA2 gene

Vigdis Hillestad, Frank Kramer, Stefan Golz, Andreas Knorr, Kristin B. Andersson, and Geir Christensen

in Journal of Applied Physiology

J Appl Physiol 115: 1572–1580, 2013

Click and read


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