Front Page from IEMR årsrapport 2012

Institute for Experimental Medical Research (IEMR)

Institutt for eksperimentell medisinsk forskning (IEMF): www.iemf.no
Head of Institute: Professor Ole M. Sejersted, MD, Ph.D.

Address: Institute for Experimental Medical Research (IEMR),
Oslo University Hospital, Ullevål,
Kirkeveien 166, NO-0407 Oslo, Norway

Phone: +47 23 01 68 00 Fax: +47 23 01 67 99

Please read the documents:
- Research Groups & Available Methods
- VISION AND STRATEGY, IEMR
- IEMR Annual report 2012

FEBS J

Latest publication (May 2013)

Kristin V. Engebretsen, Ida G. Lunde, Mari E. Strand, Anne Waehre, Ivar Sjaastad, Henriette Marstein, Biljana Skrbic, Christen P. Dahl, Erik T. Askevold, Geir Christensen, Johannes L. Bjornstad, Theis Tønnessen,

Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and pro-inflammatory stimuli

FEBS J,
Accepted for publication: March 5, 2013
DOI: 10.1111/febs.12235

Kate Herum, forskningspriser-ous-april 2013

Kate M. Herum received the Oslo University Hospital's price for Outstanding Research Article

Awarded article:
Herum KM, Lunde IG, Skrbic B, Florholmen G, Behmen D, Sjaastad I, Carlson CR, Gomez MF, Christensen G.
Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress.
Journal of Molecular and Cellular Cardiology, 2013 Jan;54:73-81.
Click and read

Five other research groups at Oslo University Hospital also got recognition. This price is awarded by Oslo University Hospital every 6 months for high quality articles that shows important findings in the short and long term. Click to read more

Cardiovascular Research

Latest publication (April 2013)

Mathis K. Stokke, Nils Tovsrud, William E. Louch, Leiv Øyehaug, Karina Hougen, Ole M. Sejersted, Fredrik Swift, Ivar Sjaastad

ICaL inhibition prevents arrhythmogenic Ca2+ waves caused by abnormal Ca2+ sensitivity of RyR or SR Ca2+ accumulation

Cardiovascular Research
Accepted 11 February 2013
doi:10.1093/cvr/cvt037

FEBS J

Latest publication (March 2013)

Mari E. Strand, Kate M. Herum, Zaheer A. Rana, Biljana Skrbic, Erik T. Askevold, Christen P. Dahl, Maria Vistnes, Almira Hasic, Heidi Kvaløy, Ivar Sjaastad, Cathrine R. Carlson, Theis Tønnessen, Lars Gullestad, Geir Christensen, and Ida G. Lunde

Innate immune signalling induces expression and shedding of the heparan sulphate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart

FEBS Journal
Accepted for publication: 28 January 2013
Doi:10.1111/febs.12161

Journal of Molecular and Cellular Cardiology

Latest publication (February 2013)

William E. Louch, Johan Hake, Halvor K. Mørk, Karina K. Hougen, Biljana Skrbic, Daniel Ursu, Theis Tønnessen, Ivar Sjaastad, Ole M. Sejersted

Slow Ca2+ sparks de-synchronize Ca2+ release in failing cardiomyocytes: evidence for altered configuration of Ca2+ release units?

Journal of Molecular and Cellular Cardiology
Accepted: January 2013
Doi: 10.1016/j.yjmcc.2013.01.014. [Epub ahead of print]

Interface Focus

Latest publication (January 2013)

Sander Land, Steven A. Niederer, William E. Louch, Ole M. Sejersted, Nicolas P. Smith

Integrating multi-scale data to create a virtual physiological mouse heart.

Interface Focus, 2013.

Matrix Biology

Latest publication (December 2012)

Biljana Skrbic, Johannes L. Bjørnstad, Henriette S. Marstein, Cathrine R. Carlson, Ivar Sjaastad, Ståle Nygård, Sigrid Bjørnstad, Geir Christensen, Theis Tønnessen.

Differential regulation of extracellular matrix constituents in myocardial remodeling with and without heart failure following pressure overload

Matrix Biology, 2012.
doi: 10.1016/j.matbio.2012.11.011. [Epub ahead of print]

Journal of Molecular and Cellular Cardiology

Latest publication (November 2012)

Kate M. Herum, Ida G. Lunde, Biljana Skrbic, Geir Florholmen, Dina Behmen, Ivar Sjaastad, Cathrine R. Carlson, Maria F. Gomez, and Geir Christensen

Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress

Journal of Molecular and Cellular Cardiology.
Accepted: 22. november, 2012
Doi: 10.1016/j.yjmcc.2012.11.006. [Epub ahead of print]

Maria Vistnes 5x7

Doctoral Thesis: 26th of November, 2012

Cand. med. Maria Vistnes has defended her thesis for the degree of Ph.D. (philosophiae doctor)

Cytokines and extracellular matrix in heart failure

Trial lecture: Immune-mediated cellular adaptations in heart failure: potential therapeutic targets

Trial lecture: 26th of November, 9:00 am
Dissertation: 26th of November, 11:00 am

Venue: Auditorium, Kreftsenteret, Building 11, Oslo University Hospital Ullevål

Supervisor: Professor Geir Christensen, Institute of Clinical Medicine, University of Oslo

Theresa Olasveengen 5x7

Theresa Olasveengen received the Max Harry Weil Award 2012 during the American Heart Association Conference in L.A.

The Max Harry Weil Award honors the memory of Max Harry Weil, MD, PhD, considered the “father of critical care medicine” and a pioneer in 3CPR science. This award was established in 2012 and acknowledges the accomplishments of young investigators and to encourage investigators to continue their research in biomedical sciences relevant to the mission and scope of the 3CPR council.

Theresa Olasveengen received the award during the annual council dinner at AHA Scientific Sessions in Los Angeles, USA last November 6, 2012.

OUS-foto-Ram-Gupta-2012-hires (Swift)

Fredrik Swift received the Oslo University Hospital's price for Outstanding Research Article

Five other research groups at Oslo University Hospital also got recognition. This price is awarded by Oslo University Hospital every 6 months for high quality articles that shows important findings in the short and long term. Every winner receives 50000 kroner in support of their research.

The article of Fredrik Swift which received the award:

Fredrik Swift, Clara Franzini-Armstrong, Leiv Øyehaug, Ulla Helene Enger, Kristin Brevik Andersson, Geir Christensen, Ole M. Sejersted, and William E. Louch

Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling following Serca2 knockout

Proc.Natl.Acad.Sci.U.S.A., 2012;109:3997-4001.

Click and read

Experimental Lung Research

Latest publication (August 2012)

Fadila Telarevic Cero, Vigdis Hillestad, Else Marit Løberg, Geir Christensen, Karl-Otto Larsen, and Ole Henning Skjønsberg

IL-18 and IL-12 synergy induces matrix degrading enzymes in the lung

Experimental Lung Research
Accepted July 26, 2012
DOI: 10.3109/01902148.2012.716903

Physiology

Latest publication (October 2012)

William E. Louch, Mathis K. Stokke, Ivar Sjaastad, Geir Christensen, and Ole M. Sejersted

No rest for the weary: Diastolic calcium homeostasis in the normal and failing myocardium

Physiology, 2012;27:308-323.

Click and read

Cardiology

Latest publications (September 2012)

Peter Majak, Johannes L. Bjørnstad, Bjørn Braathen, Ida G. Lunde, Trygve Husebye, Geir Christensen, Theis Tønnessen

Endothelin-1 in the human myocardium and circulating plasma: Evaluation before, during and after correction of aortic stenosis with aortic valve replacement

Cardiology
Accepted after revision: May 20, 2012
Published online: August 17, 2012
DOI: 10.1159/000339756

Cardiovascular Research

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Fredrik Swift and Geir Christensen

Calcium release units in heart failure: that's about the size of it

Cardiovasc. Res, 2012;95:397-398

Journal of Physiology

Latest publication (July 2012)

Sander Land, Steven A. Niederer, Jan Magnus Aronsen, Emil K. S. Espe, Lili Zhang, William E. Louch, Ivar Sjaastad, Ole M. Sejersted, Nicolas P. Smith;

An analysis of deformation dependent electromechanical coupling in the mouse heart

Journal of Physiology, 2012;590:4553-4569

American Journal of Physiology Heart Circulatory Physiology

Latest publications (June 2012)

William E. Louch, Peter Vangheluwe, Virginie Bito, Luc Raeymaekers, Frank Wuytack, Karin R. Sipido

Phospholamban ablation in hearts expressing the high affinity SERCA2b isoform normalizes global Ca2+ homeostasis but not Ca2+ -dependent hypertrophic signaling

American Journal of Physiology - Heart and Circulatory Physiology,2012;302,H2574-2582.

PLOS ONE (LOGO)

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Travis L. Dutka, Esther Verburg, Noni Larkins, Kristin H. Hortemo, Per K. Lunde, Ole M. Sejersted, Graham D. Lamb

ROS-Mediated decline in maximum Ca2+ -activated force in rat skeletal muscle fibers following in vitro and in vivo stimulation

Plos One, 2012;7:e35226
Accepted for publication: March 13, 2012

Anne Wæhre 5x7

Doctoral Thesis: 4th of June, 2012

Cand.med. Anne Wæhre has defended her thesis for the degree of Ph.D. (philosophiae doctor):

Chemokines in cardiac remodelling and heart failure, and their role in regulation of small leucine-rich proteoglycans in the extracellular matrix.

Trial lecture: Kardiomyopati hos barn – årsaker, utredning og behandling.

Trial lecture: 4th of June, 10:15 am
Dissertation: 4th of June, 13:15 am

Venue: Auditorium 1 (grønt), Rikshospitalet, Sognsvannsveien 20, Oslo

Supervisor: Professor Geir Christensen, Institute of Clinical Medicine, University of Oslo

Helge Røsjø 5x7

Doctoral Thesis: 1st of June, 2012

Cand.med. Helge Rørvik Røsjø has defended his thesis for the degree of Ph.D. (philosophiae doctor):

The granin protein family in cardiac disease.

Trial lecture: The heart as an endocrine organ.

Trial lecture: 1. June, 10:15 am
Dissertation: 1. June, 13:15 am

Venue: Store auditorium, Akershus universitetssykehus, Lørenskog

Supervisor: Professor Torbjørn Omland, Institute of Clinical Medicine, University of Oslo

Journal of Applied Physiology, vol 112, number 8

Latest publication (May 2012)

Anne Wæhre, Maria Vistnes, Ivar Sjaastad, Ståle Nygård, Cathrine Husberg, Ida Gjervold Lunde, Pål Aukrust, Arne Yndestad, Leif E. Vinge, Dina Behmen, Christian Neukamm, Henrik Brun, Erik Thaulow and Geir Christensen

Chemokines regulate small leucine-rich proteoglycans in the extracellular matrix of the pressure-overloaded right ventricle

The Journal of Applied Physiology, 2012;112:1372-1382.

Ida Gjervold Lunde 5x7

Doctoral Thesis: 10th of May 2012

M.Sc. Ida Gjervold Lunde has defended her thesis for the degree of Ph.D. (philosophiae doctor):

"Molecular mechanisms of heart failure; Nuclear Factor of Activated T-cell (NFAT) signaling in myocardial hypertrophy and dysfunction"

Trial lecture: "Strengths and limitations in use of animal models and model organisms for human heart failure research."

Trial lecture: May 10, 2012, 10:15 am
Dissertation: May 10, 2012, 13:15 am

Venue: Green Auditorium, Building 25 (Lab bldg.), Oslo University Hospital, Ullevål, Kirkeveien 166

Supervisors: Cathrine R. Carlson and Professor Geir Christensen,
Institute of Clinical Medicine, University of Oslo

Prisvinnere Ida og Alexandra

Alexandra Finsen and Ida G. Lunde receives Oslo University Hospital's price on Outstanding Research Article for 2nd half-year of 2011

Finsen AV, Lunde IG, Sjaastad I, Østli EK, Lyngra M, et al.

Syndecan-4 Is Essential for Development of Concentric Myocardial Hypertrophy via Stretch-Induced Activation of the Calcineurin-NFAT Pathway.

PLoS ONE 6(12): e28302. doi:10.1371/journal.pone.0028302
OPEN ACCESS Freely available online

Click and read

In order to stimulate excellent research and draw attention to the hospital's extensive research activity, Oslo University Hospital reward outstanding publications regularly. Every half-year, six of the very best papers authored by OUS-scientists are selected.

Biophysical Journal vol 102

Latest publication (April 2012)

Liren, Li, William E. Louch, Steven A Niederer, Jan M. Aronsen, Geir Christensen, Ole M. Sejersted, and Nicolas P. Smith

Sodium Accumulation in SERCA Knockout-Induced Heart Failure.

Biophysical Journal, 2012;102:2039-2049

Cecilie Sjåland 5x7

Doctoral Thesis: 12th of April 2012

M.Sc. Cecilie Sjåland has defended her thesis for the degree of Ph.D. (philosophiae doctor):

Physiological consequences of targeted loss of SERCA2 in heart and skeletal muscle

Trial lecture:The role of the 3Na+/2K+ pump and other P-type transport ATPases in health and disease.

Trial lecture: 12. apr. 2012, 10:15 am
Dissertation: 12. apr. 2012, 12:15 am

Venue: Store auditorium, Oslo universitetssykehus HF, Ullevål, Kirkeveien 166, Oslo
Supervisor: Professor Ole M. Sejersted,
Institute of Clinical Medicine, University of Oslo

Resuscitation March 2012

Latest publications (March 2012)

Theresa M. Olasveengen, Lars Wik, Kjetil Sunde, Petter A. Steen

Outcome when adrenaline (epinephrine) was actually given vs. not given – posthoc analysis of a randomized clinical trial

Resuscitation, 2012:83:327–332.

Magnetic Resonance in Medicine Vol 67 Issue 4

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Emil K. S. Espe, Jan Magnus Aronsen, Biljana Skrbic, Vidar Magne Skulberg, Jürgen E. Schneider, Ole M. Sejersted, Lili Zhang, Ivar Sjaastad

Improved MR phase contrast velocimetry utilizing a novel nine-point balanced motion encoding scheme with increased robustness to eddy current effects

Magnetic Resonance in Medicine
Article first published online: 5 March 2012, doi: 10.1002/mrm.24226

PNAS March 6, 2012 vol. 109 no. 10

Latest publication (February 2012)

Fredrik Swift, Clara Franzini-Armstrong, Leiv Øyehaug, Ulla Helene Enger, Kristin Brevik Andersson, Geir Christensen, Ole M. Sejersted, and William E. Louch

Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling following Serca2 knockout

Proc.Natl.Acad.Sci.U.S.A., 2012;109:3997-4001.

Click and read

Øystein Tømte 5x7

Doctoral Thesis: 17th of February 2012

Øystein Tømte, M.D. has defended his thesis for the degree of Ph.D. (philosophiae doctor):

"Out-of-hospital cardiac arrest - improving cardiopulmonary resuscitation and post resuscitation care"

Trial lecture: "The Experimental Basis for Therapeutic Hypothermia after Brain Ischemia: How Cold, How Long and How Late Can You Start."

Trial lecture: 17. feb. 2012, 10:15
Dissertation: 17. feb. 2012, 13:15

His thesis work was carried out at the Institute for Experimental Medical Research in collaboration with the Department of Anaesthesiology, Oslo University Hospital.

Venue: Rødt auditorium, Laboratoriebygget, Oslo University Hospital, Ullevaal, Kirkeveien 166

Supervisors: Professor Kjetil Sunde, MD, PhD and Lars Wik, MD, PhD

Cardiovascular Research December 1 2011

Latest publication (January 2012)

Johannes L. Bjørnstad, Biljana Skrbic, Henriette S. Marstein, Almira Hasic, Ivar Sjaastad, William E. Louch, Geir Florholmen, Geir Christensen, and Theis Tønnessen

Inhibition of SMAD2 phosphorylation preserves cardiac function during pressure overload

Cardiovascular Research,2012:93:100–110

60 year anniversary

60th Year Anniversary

The Institute for Experimental Medical Research (IEMR) was established in 1951 at the initiative of Carl B. Semb, Professor of Surgery, and made possible through a grant from shipowner Anders Jahre. Since then more than 120 Doctoral theses have been published at the Institute.

We proudly present an overview of Candidates and Doctoral Theses:

- Survey of Doctoral theses and Candidates, Institute for Experimental Medical Research, OUS 2009-2011.

- Survey of Doctoral theses and Candidates, Institute for Experimental Medical Research, UUS 1957-2009.

To read more about IEMR click here .

PLOS ONE (LOGO)

Latest publication (November 2011)

Alexander V. Finsen, Ida G. Lunde, Ivar Sjaastad, Even K. Østli, Marianne Lyngra, Hilde O. Jarstadmarken, Almira Hasic, Ståle Nygård, Sarah A. Wilcox-Adelman, Paul F. Goetinck, Torstein Lyberg, Biljana Skrbic, Geir Florholmen, Theis Tønnessen, William E. Louch, Srdjan Djurovic, Cathrine R. Carlson, Geir Christensen

Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway

Plos One, 2011;6:e28302.

Heart Failure Reviews oct 2011

Latest publication (October 2011)

Tommy Rehn, Morten Munkvik, Per Kristian Lunde, Ivar Sjaastad, Ole M. Sejersted.

Intrinsic skeletal muscle alterations in chronic heart failure patients: a disease-specific myopathy or a result of deconditioning?

Heart Failure Reviews, 2012;17:421-436.

The Journal of physiology Volume 589, Issue 21, November 2011

Latest publications (September 2011)

Cecilie Sjåland, Per Kristian Lunde, Fredrik Swift, Morten Munkvik, Madelene Ericsson, Marianne Lunde, Sigurd Boye, Geir Christensen, Øyvind Ellingsen, Ole M. Sejersted and Kristin B. Andersson

Slowed Relaxation and Preserved Maximal Force in Soleus Muscles of Mice with Targeted Disruption of the Serca2 gene in Skeletal Muscle.

The Journal of physiology, 2011;589:6139-6155.

Acta_Anaesthesiologica_Scandinavica_Cover

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Andres Neset, Tonje S. Birkenes, T. Furunes, He. Myklebust, R. J. Mykletun, Silje Ødegaard, Theresa Mariero Olasveengen and Jo Kramer-Johansen

A randomized trial on elderly laypersons’ CPR performance in a realistic cardiac arrest simulation.

Acta Anaesthesiologica Scandinavica, 2012;56:124-131.

20110818 Fredrik Kiil 2011

Fredrik Kiil 90 Year Anniversary

Professor emeritus Fredrik Kiil, M.D., Ph.D. (29. september 1921-) . Head of Institute for Experimental Medical Research (IEMR) 1962 - 1991.

Fredrik Kiil was borne in Narvik, Norway and graduated from University of Oslo in 1948. Ph.D. Oslo University 1958. He became specialist in internal medicine in 1961, and served as Head of IEMR 1961 - 1991. Fredrik Kiil was visiting professor at University of Texas Southwestern Medical School, Dallas, U.S.A., 1961.

Fredrik Kiil pioneered the development of the artificial kidney and his version, first produced at the IEMR, found use in many countries throughout the world. His extensive medical research activity covers ureteral, renal and cardiovascular physiology.

Awards: Anders Jahre's Prize for Medicine 1980. National Kidney Foundation Dialysis Pioneering Award 1982 (U.S.A.). Knight of the Order of St. Olav 1991

Read more about Fredrik Kiil in "Store norske leksikon"
Click here to see an image of the Kiil artificial kidney

Haakon Kiil Grøgard 300dpi7x5

Doctoral Thesis: 23rd September 2011

Cand.med. Haakon Kiil Grøgaard has defended his thesis for the degree of dr.philos. (doctor philosophiae):

Progenitor cells, growth factors and inflammation in acute myocardial infarction.

Trial lecture: Koronar CT angiografi i utredningen av mistenkt kransarteriesykdom

Trial lecture: Sept. 23, 2011, 10:15 am
Dissertation: Sept. 23, 2011, 14:15 pm

Venue: Rødt Auditorium, Laboratoriebygget, Oslo universitetssykehus HF, Ullevål, Kirkeveien 166

Veileder: Professor Arnfinn Ilebekk

COVER 9th CHFR

Prize winners of the Poster Session

Posters which got first prize from our Institute during the 9th Annual CHFR Symposium held last Sept. 15-16, 2011 at the Hollmenkollen Park Hotel Rica, Oslo:

William E. Louch, et al. with poster entitled: "P27 Causes and consequences of cardiomyocyte Na+ loading following SERCA2 knockout"
Anton Baysa, et al. with poster entitled: "The role of p66Shc adaptor protein in postinfarction cardiac remodeling"
Trine Baur Opstad, et al. with poster entitled: "P44 The influence of tissue factor and tissue factor pathway inhibitor polymorphisms on thrombin generation in stable CAD patients"

Other posters from our Institute which were ranked top 3 in their sessions were posters presented by: Thomas Schwartz, Anne Wæhre, Jonas Skogestad and Anett Heilebø Ottesen. Congratulations!

More information: Center for Heart Failure Research

Ole Sejersted, August Scientist of the Month 2011

Scientist of the Month

Head of Institute Professor Ole M. Sejersted is selected as Scientist of the Month by the South-Eastern Norway Regional Health Authority.

Read the interview with the August Scientist of the Month at
Helse Sør-Øst, Aktuelt

AJP Lung Cellular Molecular Physiology

Latest publication (July 2011)

Karl-Otto Larsen, Arne Yndestad, Ivar Sjaastad, Else Marit Løberg, Ingeborg Løstegaard Goverud, Bente Halvorsen, Jing Jia, Arne K. Andreassen, Cathrine Husberg, Sofia Jonasson, Martin Lipp, Geir Christensen, Pål Aukrust and Ole Henning Skjønsberg

Lack of CCR7 induces pulmonary hypertension involving perivascular leukocyte infiltration and inflammation

American Journal of Physiology Lung Cellular Molecular Physiology, 2011;301:L50-L59

Journal of Molecular and Cellular Cardiology, volume 51 2011

Latest publication (June 2011)

William E. Louch, Katherine A. Sheehan, Beata M. Wolska

Methods in cardiomyocyte isolation, culture, and gene transfer

Journal of Molecular and Cellular Cardiology, 2011;51:288-298

9th Annual CHFR Symposium

9th Annual CHFR Symposium

September 15-16, 2011 at Holmenkollen Park Hotel Rica

The meeting will be part of the official celebration of the 200th anniversary of the University of Oslo and is arranged back-to-back with the 35th Annual Meeting of the ESC Working Group on Cardiac Cellular Electrophysiology

Abstract deadline: June 6, 2011
Registration deadline: August 5, 2011

More information: Center for Heart Failure Research

35th Meeting of the European Working Group on Cardiac Cellular Electrophysiology

ESC Working Group on Cardiac Cellular Electrophysiology

The 35th Meeting of the European Working Group on Cardiac Cellular Electrophysiology takes place in Oslo on September 17-19, 2011.
More information: www.ewgcce2011.no

Johannes L. Bjørnstad 5x7

Doctoral Thesis: 10th of June, 2011

Johannes Lagethon Bjørnstad, M.D. has defended his thesis for the degree of dr. philos. (doctor philosophiae):

"The TGF-β/SMAD signalling system and extracellular matrix changes in myocardial remodelling and reverse remodelling following correction of pressure overload "

Trial lecture "Nåværende og framtidige behandling av aortklaffesykdom"

Trial lecture: June 10, 2011, 10.15
Dissertation: June 10, 2011, 13.15

Venue: Gamle festsal, Urbygningen, Karl Johans gate 47, Oslo

Supervisor: Professor Theis Tønnessen

Mathis Frøshaug Stokke 7x10

Disputas 8. jun. 2011

Cand.med. Mathis Korseberg Stokke
ved Institutt for klinisk medisin, Hjerte-, lunge- og karklinikken vil forsvare sin avhandling for graden ph.d. (philosophiae doctor)

"SERCA2-RyR2 interplay at the heart of Ca2+ wave development. Experimental studies on mechanisms underlying triggered arrhythmias."

Disputas 8. jun. 2011 13:15, Auditoriet i Kreftsenteret, Oslo universitetssykehus HF, Ullevål, Kirkeveien 166, Oslo

Prøveforelesning 8. jun. 2011 10:15 (Auditoriet i Kreftsenteret, Oslo universitetssykehus HF, Ullevål, Kirkeveien 166, Oslo) -
"Electophysiological basis for ventricular arrhythmias"

Resuscitation, Volume 82, Issue 9 , Pages 1186-1193, September 2011.

Latest publication (May 2011)

Øystein Tømte, Geir Øystein Andersen, Dag Jacobsen, Tomas Drægni, Bjørn Auestad, Kjetil Sunde Hide

Strong and weak aspects of an established post-resuscitation treatment protocol—A five-year observational study.

Resuscitation, 2011;82:1186-1193

PLOS ONE (LOGO)

Latest publications (April 2011)

Anne Waehre, Bente Halvorsen, Arne Yndestad, Cathrine Husberg, Ivar Sjaastad, Ståle Nygård, Christen P. Dahl, M. Shakil Ahmed, Alexandra V. Finsen, Henrik Reims, William E. Louch, Denise Hilfiker-Kleiner, Leif E. Vinge, Borghild Roald, Håvard Attramadal, Martin Lipp, Lars Gullestad, Pål Aukrust, and Geir Christensen.

Lack of Chemokine Signaling through CXCR5 Causes Increased Mortality, Ventricular Dilatation and Deranged Matrix during Cardiac Pressure Overload.

PLoS ONE 6(4): e18668
Accepted for publication: April 18, 2011
doi:10.1371/journal.pone.0018668

Journal of Applied Physiology , April 2011, 110 (4)

Latest publication (April 2011)

Ida Gjervold Lunde, Heidi Kvaløy, Bjørg Austbø, Geir Christensen, and Cathrine R. Carlson

Angiotensin II and norepinephrine activate specific calcineurin-dependent NFAT transcription factor isoforsm in cardiomyocytes

Journal of Applied Physiology, 2011;110:1278-1289
Accepted for publication: April 6, 2011
doi:10.1152/japplphysiol.01383.2010

The Journal of Physiology; Volume 589, Issue 6, pages 1443–1454, March 2011

Latest publication (March 2011)

Ida G. Lunde, Siobhan L. Anton, Jo C. Bruusgaard, Zaheer A. Rana, Stian Ellefsen, Kristian Gundersen

Hypoxia inducible factor 1α links fast-patterned muscle activity and fast muscle phenotype in rats

The Journal of Physiology, 2012;589:1443–1454.

Cell Physiology (March 2011)

Latest publication (February 2011)

Pimthanya Wanichawan, William E. Louch, Kristin H. Hortemo, Bjørg Austbø, Per Kristian Lunde, John D. Scott, Ole M. Sejersted, and Cathrine R. Carlson

Full length cardiac Na+-Ca2+ exchanger (NCX1) protein is not phosphorylated by protein kinase A (PKA)

American Journal of Physiology - Cell Physiology, 2011;300:C989-C997.

The Application of Organelle Proteomics to Heart Failure (February 2011) Husberg

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Giulio Agnetti, Cathrine Husberg, Jennifer E. Van Eyk

Divide and Conquer: The Application of Organelle Proteomics to Heart Failure

Circulation Research, 2012;108:512-526

Hjerte (utdrag)

Careers: open position as PhD student

A PhD student position is available at Institute for Experimental Medical Research. The project is entitled: «Outrunning the wild at heart. Exercise training as anti-arrhythmic therapy in heart failure»
Read more...
- Stillingsannonse
- PhD prosjekt om trening og hjertestans: 3-årig stipend med mulighet for umiddelbar tiltredelse

Nasjonalforeningen for folkehelse LOGO

The Heart Prize 2011

The Norwegian Council for Cardiovascular Diseases has honored professor Geir Christensen for his research on the importance of hormone production in the heart, and his efforts to establish the Center for Heart Failure Research. His Majesty King Harald presented the Heart Prize 2011 to Geir Christensen at an award ceremony in Oslo.

Cardiovascular Research Advance Access

Latest publication (February 2011)

Mathis K. Stokke, Sarah J. Briston, Guro F. Jølle, Isma Manzoor, William E. Louch, Leiv Øyehaug, Geir Christensen, David A. Eisner, Andrew W. Trafford, Ole M. Sejersted, and Ivar Sjaastad

Ca2+ wave probability is determined by the balance between SERCA2-dependent Ca2+ reuptake and threshold SR Ca2+ content.

In Cardiovascular Research Advance Access published February 7, 2011
doi:10.1093/cvr/cvr013

Annals of the Rheumatic Diseases Feb2011

Latest publication (February 2011)

Thomas Schwartz, Helga Sanner, Trygve Husebye, Berit Flatø, Ivar Sjaastad

Cardiac dysfunction in juvenile dermatomyositis: a case-control study

In Annals of the Rheumatic Diseases
Ann Rheum Dis doi:10.1136/ard.2010.137968

Critical Care Medicine 2011 vol 39

Latest publication (January 2011)

Tømte Øystein, Tomas Drægni, Arild Mangschau, Dag Jacobsen, Bjorn Auestad B. Kjetil Sunde

A comparison of core and surface cooling techniques in cardiac arrest survivors

Critical Care Medicine, 2011;36:443-449

operation theatre

Constructions at IEMR

After a long period with a lot of construction work at the Institute, the new laboratory facilities on 4th floor are now ready to use. We have also got new offices and new operation theaters on 5th floor.

Magnet

New MR

Our new Varian 9.4 T MR machine is now installed and the first experiments have been performed.

Webmaster Vidar, IEMF