Institute for Experimental Medical Research (IEMR)

Institutt for eksperimentell medisinsk forskning (IEMF)
Head of Institute: Professor Ole M. Sejersted, MD, Ph.D.

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Please read the documents:
- Research Groups & Available Methods
- IEMR Annual report 2014 (PDF) (e-paper)

Mari Elen Strand 5x7

Doctoral Thesis: 18th. of February 2016

Cand.med. Mari Elen Strand will defend her thesis for the degree of Ph.D. (philosophiae doctor): The extracellular matrix in heart failure: Proteoglycans and collagens as regulators of inflammation, fibrosis and cardiac dysfunction.

Trial lecture:
Current Understanding of the Pathophysiology of Heart Failure.

Trial lecture: 18. feb. 2016 10:15

Dissertation: 18. feb. 2016 13:15

Venue: Rødt auditorium, Laboratoriebygget (bygg 25), Ullevål sykehus, Kirkeveien 166, Oslo

Supervisor: postdoc. Ida Gjervold Lunde, Institute of Clinical Medicine, University of Oslo


JBC -Journal of Biological Chemistry cover

Latest publication

Tandekile Lubelwana Hafver, Kjetil Hodne, Pimthanya Wanichawan, Jan Magnus Aronsen, Bjørn Dalhus, Per Kristian Lunde, Marianne Lunde, Marita Martinsen, Ulla Helene Enger, William Fuller, Ivar Sjaastad, William Edward Louch, Ole Mathias Sejersted and Cathrine Rein Carlson

Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger1 Regulates its Activity by Dephosphorylating Serine 68 Phosphorylated Phospholemman

doi: 10.1074/jbc.M115.677898

Read the article in JBC -Journal of Biological Chemistry.

Rheumatology December 2015  54 (12)

Latest publication

Zoltan Barth, Birgit Nomeland Witczak, Thomas Schwartz, Knut Gjesdal, Berit Flatø, Akos Koller, Helga Sanner and Ivar Sjaastad.

In juvenile dermatomyositis, heart rate variability is reduced, and associated with both cardiac dysfunction and markers of inflammation: a cross-sectional study median 13.5 years
after symptom onset

doi: 10.1093/rheumatology/kev376

Read the article in Rheumatology .

Mani Sadredini 5x7

Medical Student Research Programme (Forskerlinjen)

Mani Sadredini has passed the final oral examination for the Medical Student Research Programme (Forskerlinjen).
Project title: "Arrhythmogenic sarcoplasmic reticulum Ca2+ release after myocardial infarction"


Our next candidate will be Åsmund Treu Røe. Project title: "Cellular mechanisms of diastolic heart failure". The oral examination will be held at Sogn Arena, 27th. November 13:00.

Read more about Forskerlinjen ...

Journal of Molecular and Cellular Cardiology oct2015

Latest publication

Mari E. Strand, Jan Magnus Aronsen, Bjørn Braathen, Ivar Sjaastad, Heidi Kvaløy, Theis Tønnessen, Geir Christensen, Ida G. Lunde

Shedding of syndecan-4 promotes immune cell recruitment and mitigates cardiac dysfunction after lipopolysaccharide challenge in mice

J.Mol.Cell.Cardiol. 2015;88:133-144

Read the article in Journal of Molecular and Cellular Cardiology.


Prize winners of the Poster Session

Presentations from our Institute which got first prize during the 13th Annual CHFR Symposium:
Ragnhild Askeland Sandbu: Chromogranin A is glycosylated in acute heart failure and this is associated with reduced processing to the functional peptide catestatin and increased mortality
David Lipsett: BIN1 regulates t-tubule growth during cardiac development and disease
Camilla Udjus: The role of caspase-1 in pulmonary hypertension

Other posters from our Institute which were ranked top 3 in their sessions, were presented by:
Ida Gjervold Lunde, Ravinea Manotheepan, Jonas Skogestad, Terje Kolstad and Emil Espe.


See all the Prize winners at Center for Heart Failure Research

journal_of_physiology 2015

Latest publication

Fadila Telarevic Cero, Vigdis Hillestad, Ivar Sjaastad, Arne Yndestad, Pål Aukrust, Trine Ranheim, Ida Gjervold Lunde, Maria Belland Olsen, Egil Lien, Lili Zhang, Solveig Bjærum Hugstad, Else Marit Løberg, Geir Christensen, Karl-Otto Larsen and Ole Henning Skjønsberg.

Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice.

Am J Physiol Lung Cell Mol Physiol 309: L378–L387, 2015

Read the article in American Journal of Physiology. Lung Cellular and Molecular Physiology.

Michael Frisk 5x7

Doctoral Thesis: 9th. September 2015

M.Sc. Michael Frisk will defend his thesis for the degree of Ph.D. (philosophiae doctor): Structure and function of cardiac t-tubules in health and disease.

Trial lecture: Role of epigenetic mechanisms in the pathophysiology of cardiovascular disease.

Trial lecture: 9. sep. 2015 10:15

Dissertation: 9. sep. 2015 13:15

Venue: Rødt auditorium, Laboratoriebygget (bygg 25), Ullevål sykehus, Kirkeveien 166, Oslo

Supervisor: Professor William E. Louch, Institute of Clinical Medicine, University of Oslo


Clinical Chemistry - August 2015; 61 (8)  cover

Latest publication

Helge Røsjø, Mai Britt Dahl, Marit Jørgensen, Ragnhild Røysland, Jon Brynildsen, Alessandro Cataliotti, Geir Christensen, Arne Didrik Høiseth, Tor-Arne Hagve and Torbjørn Omland

Influence of Glycosylation on Diagnostic and Prognostic Accuracy of N-Terminal Pro-B-Type Natriuretic Peptide in Acute Dyspnea: Data from the Akershus Cardiac Examination 2 Study.

Clin Chem. 2015 Aug;61(8):1087-97.
doi: 10.1373/clinchem.2015.239673.
Epub 2015 Jun 8.

Read the article in Clinical Chemistry

CHFR 13 logo

13th Annual CHFR Symposium on Heart Failure

Wednesday September 23 NORHEART seminar
Thursday 24 to Friday September 25 Annual CHFR Symposium

Holmenkollen Park Hotel, Oslo, Norway

The symposium arranged by Center for heart failure research is open to all clinical and basic researchers, and provides a unique meeting place for regional, national and international interaction.

All seminar attendees must register. There is no registration fee.
Registration before August 13, 2015.

Click here for more information and registration.

The Journal of Physiology cover 2015

Latest publication

William E. Louch, Jussi T. Koivumäki and Pasi Tavi

Calcium signalling in developing cardiomyocytes: implications for model systems and disease

J Physiol, Volume 593, Issue 5, pages 1047–1063, 1 March 2015

DOI: 10.1113/jphysiol.2014.274712

Read the article in The Journal of Physiology

Journal of the American College of Cardiology (JACC) 2015

Latest publication

Ottesen AH, Louch WE, Carlson CR, Landsverk OJ, Kurola J, Johansen RF, Moe MK, Aronsen JM, Høiseth AD, Jarstadmarken H, Nygård S, Bjørås M, Sjaastad I, Pettilä V, Stridsberg M, Omland T, Christensen G, Røsjø H.

Secretoneurin is a novel prognostic cardiovascular biomarker associated with cardiomyocyte calcium handling

Read paper in Journal of the American College of Cardiology (JACC)

EDITORIAL COMMENT: Will secretoneurin be the next big thing?

Read also an article in "Tidsskrift for Den norske legeforening"

Pim 5x7 300dpi A

Doctoral Thesis: 18th. June 2015

M.Sc. Pimthanya Wanichawan will defend her thesis for the degree of Ph.D. (philosophiae doctor): Molecular Regulatory Mechanisms of the Sodium-Calcium Exchanger 1 in heart..

Trial lecture: Cyclic nucleotide regulation of cardiac excitation-contraction coupling in health and disease: receptors, compartments and signalling pathways..

Trial lecture:18th June. 2015 10:15
Dissertation: 18th June 2015 13:15

Venue: Rødt auditorium, Laboratoriebygget (bygg 25), Ullevål sykehus, Kirkeveien 166, Oslo

Supervisor: Researcher Cathrine R. Carlson, Institute of Clinical Medicine, University of Oslo


Vigdis Hillestad

Doctoral Thesis: 17th. June 2015

Cand.med. Vigdis Hillestad will defend her thesis for the degree of Ph.D. (philosophiae doctor): Diastolic dysfunction and pulmonary hypertension: The role of innate immunity and new therapeutic approaches.

Trial lecture: Inflammasjonsreaksjoner som venn og fiende: Resultater fra mus - betydning for mann.

Trial lecture:17th June. 2015 10:15
Dissertation: 17th June 2015 13:15

Venue: Auditoriet i Kreftsenteret (bygg 11), Oslo universitetssykehus HF, Ullevål, Kirkeveien 166, 0407 Oslo.

Supervisor: Professor Geir Christensen, Institute of Clinical Medicine, University of Oslo



Latest publication

Åsmund T. Røe, Michael Frisk and William E. Louch
Targeting Cardiomyocyte Ca2+ Homeostasis in Heart Failure
Read more in Current Pharmaceutical Design

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286
DOI: 10.2174/138161282104141204124129


Three postdoc positions in cardiovascular research are available at IEMR

For more details and application forms, please follow the links:

Position 1: Postdoctoral Research Fellow - 3-year.
Contact Person: Geir Christensen, Professor

Position 2: Postdoctoral Research Fellow - 2-year.
Contact Person: William Louch Research Associate Professor

Position 3: Postdoctoral Position Examining Structure / Function of Cardiac Muscle Cells - 2-year.
Contact Person: William Louch, Research Associate Professor

Source: Naturejobs

Cover IEMR 2014

Annual Report IEMR 2014

I am pleased to present the Annual Report from Institute for Experimental Medical Research (IEMR) for 2014. In 2014 two important grants were started up at IEMR - a Regional Health Authority grant to Professor Geir Christensen and a grant from the Research Council of Norway to Professor Ivar Sjaastad. These grants allowed recruitment of new people to IEMR. Also other smaller grants allowed us to hire new PhD students. Altogether we had the pleasure of welcoming 17 new people to IEMR in 2014. This means that there is now a core staff of 66 people at the institute and an additional 15 employed other places do their entire project or parts of it at IEMR. Thus, we have an interactive environment and can offer access to infrastructure and provide important competence to scientists both within and outside the hospital. ( Continue reading on e-paper... )

Ole M. Sejersted
Head of Department

Kate 2014

Doctoral Thesis: 12th. March 2015

M.Sc. Kate Møller Herum will defend her thesis for the degree of Ph.D. (philosophiae doctor): Syndecan-4 in Cardiac Fibroblasts. Role in Regulation of Extracellular Matrix and Myocardial Stiffness.

Trial lecture: The roles of proteoglycans in development of atherosclerosis.

Trial lecture: 12th. March 2015 10:15
Dissertation: 12th. March 2015 13:15

Venue: Store auditorium A1.1001, Domus Odontologica, Sognsvannsveien 10, Oslo

Supervisor: Professor Geir Christensen, Institute of Clinical Medicine, University of Oslo


The European Research Council (ERC)

Consolidator Grant 2014

The European Research Council (ERC) has again selected top scientists in its Consolidator Grant competition.
On the list this year is IEMR-researcher William E. Louch (Bill).
ERC Consolidator Grants are designed to support researchers at the stage at which they are consolidating their own independent research team or programme, to give opportunities for young investigators to develop independent careers and make the transition from working under a supervisor to being independent researchers in their own right.

Well done, Bill!

Read more about Funding and Grants from ERC.

European Research Council - Supporting top researchers from anywhere in the world!

Circ Cardiovasc Imaging.

Latest publication (February 2015)

Emil k. Espe, Jon Magnus Aronsen, Guro Eriksen, Lili Zhang, Otto A. Smiseth, Tor Edvardsen, Ivar Sjaastad, & Morten Eriksen,M.

Assessment of regional myocardial work in rats

Circ Cardiovasc Imaging. 2015;8:e002695. doi: 10.1161/CIRCIMAGING.114.002695

Read more in Circulation: Cardiovascular Imaging..

Cardiovascular Research

Latest publication (January 2015)

Kate M. Herum, Ida G. Lunde, Biljana Skrbic, William E. Louch, Almira Hasic, Sigurd Boye, Andreas Unger, Sverre-Henning Brorson, Ivar Sjaastad, Theis Tønnessen, Wolfgang A. Linke, Maria F. Gomez & Geir Christensen

Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart

Cardiovascular Research. doi: http://dx.doi.org/10.1093/cvr/cvv002 First published online: 13 January 2015

Trude Aspelin

Doctoral Thesis: 15th. January 2015

Trude Aspelin will defend her thesis for the degree of Ph.D. (philosophiae doctor): Cardiac tissue plasminogen activator. Experimental studies on stimulated release, receptor interactions and β-blockade in pigs.

Trial lecture: Bakenforliggende mekanismer ved aterotromboser.

Trial lecture: 15th. Jan. 2015 10:15
Dissertation: 15th. Jan. 2015 13:15

Venue: Rødt auditorium, 1.etg. Patologibygningen (bygg 25), Ullevål sykehus, Kirkeveien 166, Oslo

Senior Scientist Torstein Lyberg, Department of Medical Biochemistry, Oslo University Hospital, Ullevål.
Professor Emeritus Arnfinn B. Ilebekk, Institute for Experimental Medical Research, Oslo University Hospital, Ullevål.

Kristin V. T. Engebretsen 5x7 just

Doctoral Thesis: 7th. January 2015

Cand.med. Kristin Victoria Tunheim Engebretsen will defend her thesis for the degree of Ph.D. (philosophiae doctor):
Extracellular matrix alterations in the pressure overloaded left ventricle.

Trial lecture: Does Transcatheter Aortic Heart Valve Implantation (TAVI) lead to beneficial effects on the left ventricle? Implication and regulatory roles of matrix proteoglycans.

Trial lecture: 7th. Jan. 2015 10:15
Dissertation: 7th. Jan. 2015 13:15

Venue: Universitetets aula, Domus Media (Midtbygningen), Karl Johans gate 47, Oslo

Supervisor: Professor II Theis Tønnessen, Division of Cardiovascular and Pulmonary Diseases, University of Oslo

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