Doctoral Thesis: 10th of May 2012
M.Sc. Ida Gjervold Lunde has defended her thesis for the degree of Ph.D. (philosophiae doctor):
"Molecular mechanisms of heart failure; Nuclear Factor of Activated T-cell (NFAT) signaling in myocardial hypertrophy and dysfunction"
Trial lecture: "Strengths and limitations in use of animal models and model organisms for human heart failure research."
Trial lecture: May 10, 2012, 10:15 am
Dissertation: May 10, 2012, 13:15 am
Green Auditorium, Building 25 (Lab bldg.), Oslo University Hospital,
Ullevål, Kirkeveien 166
Supervisors: Cathrine R. Carlson and Professor Geir Christensen,
Institute of Clinical Medicine, University of Oslo
Latest publications (April 2012)
Liren, Li, William E. Louch, Steven A Niederer, Jan M. Aronsen, Geir Christensen, Ole M. Sejersted, and Nicolas P. Smith
Sodium Accumulation in SERCA Knockout-Induced Heart Failure.
Biophysical Journal, 2012;102:2039-2049
Accepted for publication: March 16, 2012
doi: 10.1016/j.bpj.2012.03.045
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Anne Wæhre, Maria Vistnes, Ivar Sjaastad, Ståle Nygård, Cathrine Husberg, Ida Gjervold Lunde, Pål Aukrust, Arne Yndestad, Leif E. Vinge, Dina Behmen, Christian Neukamm, Henrik Brun, Erik Thaulow and Geir Christensen
Chemokines regulate small leucine-rich proteoglycans in the extracellular matrix of the pressure-overloaded right ventricle
The Journal of Applied Physiology, 2012;112:1372-1382.
First published 16 February 2012.
doi:10.1152/japplphysiol.01350.2011
Doctoral Thesis: 12th of April 2012
M.Sc. Cecilie Sjåland has defended her thesis for the degree of Ph.D. (philosophiae doctor):
Physiological consequences of targeted loss of SERCA2 in heart and skeletal muscle
Trial lecture:The role of the 3Na+/2K+ pump and other P-type transport ATPases in health and disease.
Trial lecture: 12. apr. 2012 kl. 10:15
Dissertation: 12. apr. 2012 kl. 12:15
Store auditorium, Oslo universitetssykehus HF, Ullevål,
Kirkeveien 166, Oslo
Supervisor: Professor Ole M. Sejersted,
Institute of Clinical Medicine, University of Oslo
Latest publications (March 2012)
Theresa M. Olasveengen, Lars Wik, Kjetil Sunde, Petter A. Steen
Outcome when adrenaline (epinephrine) was actually given vs. not given – posthoc analysis of a randomized clinical trial
Resuscitation, 2012:83:327–332.
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Emil K. S. Espe, Jan Magnus Aronsen, Biljana Skrbic, Vidar Magne Skulberg, Jürgen E. Schneider, Ole M. Sejersted, Lili Zhang, Ivar Sjaastad
Improved MR phase contrast velocimetry utilizing a novel nine-point balanced motion encoding scheme with increased robustness to eddy current effects
Magnetic Resonance in Medicine
Article first published online: 5 March 2012, doi: 10.1002/mrm.24226
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Thomas Schwartz, Girgis Magdi, Tore W. Steen, Ivar Sjaastad
HIV as a risk factor for cardiac disease in Botswana: a cross-sectional study
International Health, 2012;4:30-37.
Latest publication (February 2012)
Fredrik Swift, Clara Franzini-Armstrong, Leiv Øyehaug, Ulla Helene Enger, Kristin Brevik Andersson, Geir Christensen, Ole M. Sejersted, and William E. Louch
Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling following Serca2 knockout
Proc.Natl.Acad.Sci.U.S.A., 2012;109:3997-4001.
Published online before print February 21, 2012.
doi: 10.1073/pnas.1120172109
Doctoral Thesis: 17th of February 2012
Øystein Tømte, M.D. has defended his thesis for the degree of Ph.D. (philosophiae doctor):
"Out-of-hospital cardiac arrest - improving cardiopulmonary resuscitation and post resuscitation care"
Trial lecture: "The Experimental Basis for Therapeutic Hypothermia after Brain Ischemia: How Cold, How Long and How Late Can You Start."
Trial lecture: 17. feb. 2012, 10:15
Dissertation: 17. feb. 2012, 13:15
His thesis work was carried out at the Institute for Experimental Medical Research in collaboration with the Department of Anaesthesiology, Oslo University Hospital.
Venue: Rødt auditorium, Laboratoriebygget, Oslo University Hospital, Ullevaal, Kirkeveien 166
Supervisors: Professor Kjetil Sunde, MD, PhD and Lars Wik, MD, PhD
Latest publication (January 2012)
Johannes L. Bjørnstad, Biljana Skrbic, Henriette S. Marstein, Almira Hasic, Ivar Sjaastad, William E. Louch, Geir Florholmen, Geir Christensen, and Theis Tønnessen
Inhibition of SMAD2 phosphorylation preserves cardiac function during pressure overload
Cardiovascular Research,2012:93:100–110
Latest publication (November 2011)
Andres Neset, Tonje S. Birkenes, T. Furunes, He. Myklebust, R. J. Mykletun, Silje Ødegaard, Theresa Mariero Olasveengen and Jo Kramer-Johansen
A randomized trial on elderly laypersons’ CPR performance in a realistic cardiac arrest simulation.
Acta Anaesthesiologica Scandinavica, 2012;56:124-131.
Accepted Sept. 1, 2011
doi: 10.1111/j.1399-6576.2011.02566.x
Latest publication (November 2011)
Cecilie Sjåland, Per Kristian Lunde, Fredrik Swift, Morten Munkvik, Madelene Ericsson, Marianne Lunde, Sigurd Boye, Geir Christensen, Øyvind Ellingsen, Ole M. Sejersted and Kristin B. Andersson
Slowed Relaxation and Preserved Maximal Force in Soleus Muscles of Mice with Targeted Disruption of the Serca2 gene in Skeletal Muscle.
The Journal of physiology, 2011;589:6139-6155.
Accepted after revision: Sept. 25, 2011
DOI: 10.1113/jphysiol.2011.211987
Latest publication (October 2011)
Rehn TA, Munkvik M, Lunde PK, Sjaastad I, Sejersted OM.
Intrinsic skeletal muscle alterations in chronic heart failure patients: a disease-specific myopathy or a result of deconditioning?
Heart Failure Reviews, 2011 Oct 14.
DOI 10.1007/s10741-011-9289-4
Latest publication (October 2011)
Johannes L. Bjørnstad, Biljana Skrbic, Ivar Sjaastad, Sigrid Bjørnstad, Geir Christensen, Theis Tønnessen
A Mouse Model of Reverse Cardiac Remodelling Following Banding-Debanding of the Ascending Aorta
Acta Physiologica, 2011 Oct 4. doi: 10.1111/j.1748-1716.2011.02369.x.
OPEN ACCESS publication
Morten Munkvik, Per Kristian Lunde, Jan Magnus Aronsen, Jon Arne Kro Birkeland, Ivar Sjaastad, Ole M. Sejersted
Attenuated Fatigue in Slow Twitch Skeletal Muscle during Isotonic Exercise in Rats with Chronic Heart Failure
PLoS One. 2011; 6(7): e22695. doi: "10.1371/journal.pone.0022695"
OPEN ACCESS Freely available online
Fredrik Kiil 90 Year Anniversary
Professor emeritus Fredrik Kiil, M.D., Ph.D. (29. september 1921-) . Head of Institute for Experimental Medical Research (IEMR) 1962 - 1991.
Fredrik Kiil was borne in Narvik, Norway and graduated from University of Oslo in 1948. Ph.D. Oslo University 1958. He became specialist in internal medicine in 1961, and served as Head of IEMR 1961 - 1991. Fredrik Kiil was visiting professor at University of Texas Southwestern Medical School, Dallas, U.S.A., 1961.
Fredrik Kiil pioneered the development of the artificial kidney and his version, first produced at the IEMR, found use in many countries throughout the world. His extensive medical research activity covers ureteral, renal and cardiovascular physiology.
Awards: Anders Jahre's Prize for Medicine 1980. National Kidney Foundation Dialysis Pioneering Award 1982 (U.S.A.). Knight of the Order of St. Olav 1991
Read more about Fredrik Kiil in "Store norske leksikon"
Click here to see an image of the Kiil artificial kidney
Doctoral Thesis: 23rd September 2011
Cand.med. Haakon Kiil Grøgaard ved Institutt for klinisk medisin vil forsvare sin avhandling for graden dr.philos. (doctor philosophiae):
"Progenitor cells, growth factors and inflammation in acute myocardial infarction"
Prøveforelesning: 23. sep. 2011 10:15, Rødt Auditorium, Laboratoriebygget, Oslo universitetssykehus HF, Ullevål
Selvvalgt emne: "Koronar CT angiografi i utredningen av mistenkt kransarteriesykdom" Oppgitt emne: "Behandling av akutt hjerteinfarkt i 2021"
Disputas: 23. sep. 2011 14:15, Rødt Auditorium, Laboratoriebygget, Oslo universitetssykehus HF, Ullevål, Kirkeveien 166
Veileder: Professor Arnfinn Ilebekk
Prize winners of the Poster Session
First prize winners from our Institute honored for posters and presentations at the 9th Annual CHFR Symposium:
Anton Baysa, et al. with poster titled: "The role of p66Shc adaptor protein in postinfarction cardiac remodeling"
William E. Louch, et al. with poster titled: "P27 Causes and consequences of cardiomyocyte Na+ loading following SERCA2 knockout"
Trine Baur Opstad, et al. with poster titled: "P44 The influence of tissue factor and tissue factor pathway inhibitor
polymorphisms on thrombin generation in stable CAD patients"
Among the top 3 candidates in each session, posters from IEMR were also presented by: Thomas Schwartz, Anne Wæhre, Jonas Skogestad and Anett Heilebø Ottesen. Congratulation!
More information: Center for Heart Failure Research
Latest publication (September 2011)
Øystein Tømte, Geir Øystein Andersen, Dag Jacobsen, Tomas Drægni, Bjørn Auestad, Kjetil Sunde Hide
Strong and weak aspects of an established post-resuscitation treatment protocol—A five-year observational study.
Resuscitation, Volume 82, Issue 9 , Pages 1186-1193, September 2011.
Scientist of the Month
Head of Institute Ole Sejersted is selected as Scientist of the Month by the South-Eastern Norway Regional Health Authority.
Read the interview with the August Scientist of the Month at
Helse Sør-Øst, Aktuelt
Latest publication
William E. Louch, Katherine A. Sheehan, Beata M. Wolska
Methodological review:
Methods in cardiomyocyte isolation, culture, and gene transfer
Journal of Molecular and Cellular Cardiology, Volume 51, Issue 3, September 2011, Pages 288-298
9th Annual CHFR Symposium
September 15-16, 2011 at Holmenkollen Park Hotel Rica
The meeting will be part of the official celebration of the 200th anniversary of the University of Oslo and is arranged back-to-back with the 35th Annual Meeting of the ESC Working Group on Cardiac Cellular Electrophysiology
Abstract deadline: June 6, 2011
Registration deadline: August 5, 2011
More information: Center for Heart Failure Research
ESC Working Group on Cardiac Cellular Electrophysiology
The 35th Meeting of the European Working Group on Cardiac Cellular Electrophysiology takes place in Oslo on September 17-19, 2011.
More information: www.ewgcce2011.no
Disputas 10. juni 2011
Doktorgradsprøve for graden ph.d. for Cand.med.
Johannes Lagethon Bjørnstad
ved Institutt for klinisk medisin, Det medisinske fakultet
"The TGF-β/SMAD signalling system and extracellular matrix changes in myocardial remodelling and reverse remodelling following correction of pressure overload "
Prøveforelesning fredag 10. juni 2011 kl. 10.15
Oppgitt emne:
"Nåværende og framtidige behandling av aortklaffesykdom"
Sted: Gamle festsal, Urbygningen, Karl Johans gate 47, Oslo
Disputas: Fredag 10. juni 2011 kl. 13.15
Sted: Gamle festsal, Urbygningen, Karl Johans gate 47, Oslo
Disputas 8. jun. 2011
Cand.med. Mathis Korseberg Stokke
ved Institutt for klinisk medisin, Hjerte-, lunge- og karklinikken vil forsvare sin avhandling for graden ph.d. (philosophiae doctor)
"SERCA2-RyR2 interplay at the heart of Ca2+ wave development. Experimental studies on mechanisms underlying triggered arrhythmias."
Disputas 8. jun. 2011 13:15, Auditoriet i Kreftsenteret, Oslo universitetssykehus HF, Ullevål, Kirkeveien 166, Oslo
Prøveforelesning 8. jun. 2011 10:15 (Auditoriet i Kreftsenteret, Oslo universitetssykehus HF, Ullevål, Kirkeveien 166, Oslo) -
"Electophysiological basis for ventricular arrhythmias"
Latest publications (April 2011)
Anne Waehre, Bente Halvorsen, Arne Yndestad, Cathrine Husberg, Ivar Sjaastad, Ståle Nygård, Christen P. Dahl, M. Shakil Ahmed, Alexandra V. Finsen, Henrik Reims, William E. Louch, Denise Hilfiker-Kleiner, Leif E. Vinge, Borghild Roald, Håvard Attramadal, Martin Lipp, Lars Gullestad, Pål Aukrust, and Geir Christensen.
Lack of Chemokine Signaling through CXCR5 Causes Increased Mortality, Ventricular Dilatation and Deranged Matrix during Cardiac Pressure Overload.
PLoS ONE 6(4): e18668. doi:10.1371/journal.pone.0018668.
Published April 18, 2011
PLoS ONE (open-access, online publication) is published by the Public Library of Science (PLoS), a nonprofit organization.
Latest publication (April 2011)
Ida Gjervold Lunde, Heidi Kvaløy, Bjørg Austbø, Geir Christensen, and Cathrine R. Carlson
Angiotensin II and norepinephrine activate specific calcineurin-dependent NFAT transcription factor isoforsm in cardiomyocytes
Journal of Applied Physiology , April 2011, 110 (4)
Latest publication
Giulio Agnetti, Cathrine Husberg, Jennifer E. Van Eyk
Divide and Conquer: The Application of Organelle Proteomics to Heart Failure
Circulation Research. Journal by the American Heart Association.
Volume 108, Issue 4; February 18, 2011
Circ. Res. 2011;108;512-526
Latest publication (March 2011)
Ida G. Lunde, Siobhan L. Anton, Jo C. Bruusgaard, Zaheer A. Rana, Stian Ellefsen, Kristian Gundersen
Hypoxia inducible factor 1α links fast-patterned muscle activity and fast muscle phenotype in rats
The Journal of Physiology; Volume 589, Issue 6, pages 1443–1454, March 2011
Latest publication (February 2011)
Pimthanya Wanichawan, William E. Louch, Kristin H. Hortemo, Bjorg Austbo, Per Kristian Lunde, John D. Scott, Ole M. Sejersted, and Cathrine R. Carlson
Full length cardiac Na+-Ca2+ exchanger (NCX1) protein is not phosphorylated by protein kinase A (PKA)
American Journal of Physiology - Cell Physiology
published ahead of print February 2, 2011, doi:10.1152/ajpcell.00196.2010
The Heart Prize 2011
The Norwegian Council for Cardiovascular Diseases has honored professor Geir Christensen for his research on the importance of hormone production in the heart, and his efforts to establish the Center for Heart Failure Research. His Majesty King Harald presented the Heart Prize 2011 to Geir Christensen at an award ceremony in Oslo.
Latest publication (February 2011)
Mathis K. Stokke, Sarah J. Briston, Guro F. Jølle, Isma Manzoor, William E. Louch, Leiv Øyehaug, Geir Christensen, David A. Eisner, Andrew W. Trafford, Ole M. Sejersted, and Ivar Sjaastad
Ca2+ wave probability is determined by the balance between SERCA2-dependent Ca2+ reuptake and threshold SR Ca2+ content.
In Cardiovascular Research Advance Access published February 7, 2011
doi:10.1093/cvr/cvr013
Latest publication (February 2011)
Thomas Schwartz, Helga Sanner, Trygve Husebye, Berit Flatø, Ivar Sjaastad
Cardiac dysfunction in juvenile dermatomyositis: a case-control study
In Annals of the Rheumatic Diseases
Ann Rheum Dis doi:10.1136/ard.2010.137968
Latest publication (January 2011)
Tømte Øystein., Drægni Tomas, Mangschau A. , Jacobsen D. , Auestad B. • Sunde K.
A comparison of core and surface cooling techniques in cardiac arrest survivors
In Critical Care Medicine 2011 Vol. 39 (3)
Doctoral thesis, Faculty of Medicine, UiO (Dec. 2010)
Disputas:
Cand.med. Karl-Otto Larsen ved Institutt for klinisk medisin vil forsvare sin avhandling for graden ph.d. (philosophiae doctor)
"Pulmonary hypertension and cardiac dysfunction; the role of hypoxia and cytokines" Tid og sted: 9. des. 2010 13:15,
Grønt auditorium, Laboratoriebygget, Ullevål, Kirkeveien 166
Prøveforelesning 9. des. 2010 10:15
(Grønt auditorium, Laboratoriebygget, Ullevål, Kirkeveien 166)
- Pulmonal hypertensjon hos nyfødte, barn og voksne; likheter og forskjeller?
Latest publication (October 2010)
Liu,X.H.; Zhang,Z.Y.; Andersson,K.B.; Husberg,C.; Enger,U.H.; Raeder,M.G.; Christensen,G.; Louch,W.E.
Cardiomyocyte-specific disruption of Serca2 in adult mice causes sarco(endo)plasmic reticulum stress and apoptosis.
In Cell Calcium
Latest publications (September 2010)
William E. Louch et al:
Control of Ca2+ Release by Action Potential Configuration in Normal and Failing Murine Cardiomyocytes
Biophysical Journal, Volume 99, Issue 5, 8 September 2010, Pages 1377-1386
Doctoral thesis, Faculty of Medicine, UiO (October 2010)
Disputas: Cand.med. Tommy Aune Rehn ved Institutt for klinisk medisin vil forsvare sin avhandling for graden ph.d. (philosophiae doctor) "Causes of altered skeletal muscle function in the post-infarction heart failure condition"
Tid og sted: 21. okt. 2010 13:00, Auditoriet i Kreftsenteret, Oslo universitetssykehus Ullevål, Kirkeveien 166
Prøveforelesning: 21. okt. 2010 10:00 (Auditoriet i Kreftsenteret, Oslo universitetssykehus Ullevål, Kirkeveien 166)
- Is it quality or quantity that counts - what determines skeletal muscle functional capacity?
Constructions at IEMR
After a long period with a lot of construction work at the Institute, the new laboratory facilities on 4th floor are now ready to use. We have also got new offices and new operation theaters on 5th floor.
Doctoral thesis, Faculty of Medicine, UiO (March 2010)
Disputas:
Cand.med. Morten Munkvik ved Institutt for klinisk medisin, Ullevål vil forsvare sin avhandling for graden ph.d. (philosophiae doctor) "Fatigue mechanisms and skeletal muscle function in experimental and human heart failure"
Tid og sted: 10. mar. 2010 12:15, Auditoriet i Kreftsenteret, Oslo universitetssykehus Ullevål, Kirkeveien 166
Prøveforelesning: 10. mar. 2010 09:15 (Auditoriet i Kreftsenteret, Oslo universitetssykehus Ullevål, Kirkeveien 166)
- Forbindelser mellom skjelettmuskel- og hjertemuskelbiologi hos friske mennesker og hos pasienter med hjertesvikt
New MR
Our new Varian 9.4 T MR machine is now installed and the first experiments have been performed.
