Fadila 2019

Doctoral Thesis: December 6, 2019

Cand.med. Fadila Telarevic Cero will defend her thesis “Hypoxia-Induced Pulmonary Hypertension and Cardiac Dysfunction; The Role of Inflammasomes and related Cytokines” for the degree of PhD (Philosophiae Doctor).
Given topic: "Heart failure in COPD - mechanisms, diagnosis and treatment."

Trial lecture: December 6, 2019 10:15 AM

Public Defence: December 6, 2019 1:15 PM

Venue: Auditorium 1, Kreftsenteret, Bygg 11, Oslo universitetssykehus, Ullevål, Kirkeveien 166

Supervisor: Professor II Ole Henning Skjønsberg, Faculty of Medicine, University of Oslo



Latest publication (November 2019)

Henriette Marstein, Thomas Schwartz, Trond Mogens Aaløkken, May Britt Lund, Berit Flatø, Ivar Sjaastad & Helga Sanner

Novel associations between cytokines and pulmonary involvement in juvenile dermatomyositis - a cross sectional study of long-term disease

Read the article in Rheumatology

PMID: 31740970 doi:10.1093/rheumatology/kez531

Frontiers in Cardiovascular Medicine

Latest publication (September 2019)

Raffaele Altara and George W. Booz

Editorial: Cardiac Microvascular Endothelium Contribution to Cardiac Myocyte Growth, Structure, and Contractile Function

Read the article in Frontiers in Cardiovascular Medicine

PMID: 31552274 doi: 10.3389/fcvm.2019.00130

Poster prize winner Karoline Bjarnesdatter Rypdal, 2019

Prize winners of the Poster Session, 2019

Karoline Bjarnesdatter Rypdal was awarded the first prize during the 17th Annual Symposium on Heart Research for the presentation "ADAMTSL2 is up-regulated in heart failure and directs anti-fibrotic signalling" in Session II Cellular signaling - Myocardial hypertrophy and ischemia. Referee: Burns Blaxall, University of Cincinnati College of Medicine, USA.

Jonas Skogestad was awarded the first prize in Session IV for the presentation Phosphodiesterase 2 inhibition activates the Na+/K+-ATPase and prevents ventricular tachycardia.
Referee: Dobromir Dobrev, University of Duisburg-Essen, Germany.

The poster evaluation was based on the novelty of conclusions, quality of data and clarity of presentation.

Photo: Poster prize winner of Session II Karoline Bjarnesdatter Rypdal (left) received the diploma from dr. Ravinea Manotheepan on behalf of the Organizing Committee.

Other poster presentations from our Institute ranked top 3 in their sessions, were presented by Lisa Smith, Rafaele Altara, Michael Frisk and Andreas Romaine.


List of all poster prize winners.

Click to see pictures from:

- The Annual Symposium on Heart Research 2019

- The Moderated poster sessions

- The Cardiac Café

17th Annual CHFR Symposium on Heart Research

17th Annual CHFR Symposium on Heart Research

Wednesday September 18th to Friday September 20th, 2019

- Wednesday NORHEART Cardiac Café - the place to meet and be inspired!

- Thursday to Friday 17th Annual CHFR Symposium on Heart Research. Holmenkollen Park Hotel, Oslo, Norway. The symposium arranged by Center for heart failure research and NORHEART is open to all clinical and basic researchers, and provides a unique meeting place for regional, national and international interaction.

Submission of abstracts before Monday 3rd of June
Registration before 20th of August.
Submission of presentation before Wednesday 11th of September.

All seminar attendees must register. There is no registration fee.

Click here for more information and registration.


Latest publication (July 2019)

Gary McGinley, Bård A. Bendiksen, Lili Zhang, Jan Magnus Aronsen, Einar Sjaastad Nordén, Ivar Sjaastad and Emil K. S. Espe

Accelerated magnetic resonance imaging tissue phase mapping of the rat myocardium using compressed sensing with iterative soft-thresholding

Read the article in PLOS One - Public Library of Science

PMID: 31276508 DOI: 10.1371/journal.pone.0218874

Scientific Report

Latest publication (June 2019)

Mohammadzadeh,N.; Lunde,I.G.; Andenæs,K.; Strand,M.E.; Aronsen,J.M.; Skrbic,B.; Marstein,H.S.; Bandlien,C.; Nygard,S.; Gorham,J.; Sjaastad,I.; Chakravarti,S.; Christensen,G.; Engebretsen,K.V.T.; Tønnessen,T.

The extracellular matrix proteoglycan lumican improves survival and counteracts cardiac dilatation and failure in mice subjected to pressure overload

Read the article in Scientific Reports
- an open access journal from Nature Research

PMID: 31235849 doi: 10.1038/s41598-019-45651-9

Olav 3R winner 2019

Norecopa's 3R Prize

The winner in 2019 was Arne Olav Melleby at Oslo University Hospital Ullevål, for his excellent work in developing a better operating technique for mice in research on chronic cardiac failure.

Read the paper in Cardiovascular Research describing the technique.

Norecopa is Norway's National Consensus Platform for the advancement of "the 3 Rs" (Replacement, Reduction, Refinement) in connection with animal experiments.Read more about Norecopa.

Photo: Member of Parliament Morten Ørsal Johanse handed over the Diploma for the Norecopa's 3R Prize for outstanding efforts to advance Replacement, Reduction & Refinement in connection with animal research, to the winner Arne Olav Melleby.

Journal of Biological Chemistry

Latest publication (May 2019)

Sabrina Bech Mathiesen, Marianne Lunde, Jan Magnus Aronsen, Andreas Romaine, Anita Kaupang, Marita Martinsen, Gustavo, Antonio de Souza, Tuula A. Nyman, Ivar Sjaastad, Geir Christensen, and Cathrine Rein Carlson

The cardiac syndecan-4 interactome reveals a role for syndecan-4 in nuclear translocation of muscle LIM protein (MLP)

Read the article in The Journal of Biological Chemistry

PMID: 30967474. DOI: 10.1074/jbc.RA118.006423

Zoltan Barth 2016

Doctoral Thesis: May 10, 2019

MD Zoltan Barth will defend his thesis for the degree of Ph.D. (philosophiae doctor): “Microvascular Remodelling and Autonomic Dysregulation in Juvenile Dermatomyositis”

Given topic: "Nailfold capillaroscopy findings as predictor of organ involvement in juvenile and adult systemic sclerosis (scleroderma)."

Trial lecture: May 10, 2019 10:15 AM

Dissertation: May 10, 2019 1:15 PM

Venue: Seminarrom A3 3067, Rikshospitalet, Sognsvannsveien 20

Supervisor: MD, PhD Helga Sanner, Oslo University Hospital


Am.J Physiol Lung Cell Mol.Physiol

Latest publication (April 2019)

Camilla Udjus, Fadila T. Cero, Bente Halvorsen, Dina Behmen, Cathrine R. Carlson, Bård A. Bendiksen, Emil K. Espe, Ivar Sjaastad, Else Marit Løberg, Arne Yndestad, Pål Aukrust, Geir Christensen, Ole Henning Skjønsberg and Karl Otto Larsen

Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension

Read the article in American Journal of Physiology. Lung Cellular and Molecular Physiology

PMID: 30908936 DOI: 10.1152/ajplung.00322.2018

The Journal of Rheumatology

Latest publication (March 2019)

Birgit Nomeland Witczak, Siri Opsahl Hetlevik, Helga Sanner, Zoltan Barth, Thomas Schwartz, Berit Flatø, Vibke Lilleby and Ivar Sjaastad

Effect on Cardiac Function of Longstanding Juvenile-onset Mixed Connective Tissue Disease: A Controlled Study

Read the article in The Journal of Rheumatology
DOI: 10.3899/jrheum.180526

Journal of Physiology

Latest publication (February 2019)

David D. B. Lipsett, Michael Frisk, Jan Magnus Aronsen, Einar S. Nordén, Buonarati,O.R., Alessandro Cataliotti, Hell,J.W., Ivar Sjaastad, Geir Christensen and William E. Louch

Cardiomyocyte substructure reverts to an immature phenotype during heart failure

Read the article in The Journal of Physiology

PMID:30707448. doi: 10.1113/JP277273

American Journal of Physiology-cover

Latest publication (January 2019)

Jonas Skogestad, Glenn Terje Lines, William E. Louch, Ole M. Sejersted, Ivar Sjaastad, and Jan Magnus Aronsen

Evidence for heterogeneous subsarcolemmal Na+ levels in rat ventricular myocytes

Read the article in:
American Journal of Physiology-Heart and Circulatory Physiology

PMID: 30657726 DOI: 10.1152/ajpheart.00637.2018


Funding from the Norwegian Health Association

Nasjonalforeningen for folkehelsen (the Norwegian Health Association) combats cardiovascular disease and dementia by funding research.

This year PhD student Chloe Rixon and Postdocs Ornella Manfra, Jia Li, Emil Espe, Mari Elen Strand and Maria Vistnes have all been granted funding from the Norwegian Health Association. In addition running cost contributions are given for research projects lead by Principal investigators Ida Gjervold Lunde, Mathis Korseberg Stokke and Geir Christensen.

See all the projects supported by Nasjonalforeningen for folkehelsens hjerte- og karmidler 2019.

Next application submission deadline is 1st June 2019.
Calls for project proposals:
Søk forskningsmidler fra Nasjonalforeningen for folkehelsen.

Ornella, Chloe and Jia at Nasjonalforeningen research prize ceremony.

Cover Journal of Physiology, Volume 597 Number 2, 15 January 2019

Latest publication (December 2018)

Xin Shen, Jonas van den Brink, Yufeng Hou, Dylan Colli , Christopher Le, Terje R. Kolstad ,Niall MacQuaide, Cathrine R. Carlson, Peter M. Kekenes-Huskey, Andrew G. Edwards, Christian Soeller and William E. Louch.

3D dSTORM imaging reveals novel detail of ryanodine receptor localization in rat cardiac myocytes.

"In this issue of The Journal of Physiology, Shen and colleagues have employed the super-resolution imaging technique dSTORM to quantitatively describe the 3D, nanoscale arrangement of ryanodine receptors across rat ventricular cardiomyocytes. Combining dSTORM-derived ryanodine receptor positions with confocal images of t-tubules allows appreciation of the 3D complexity and irregularity of dyadic arrangements."
The Journal of Physiology, Volume 597 Number 2, 15 January 2019

Read the article in The Journal of Physiology

J Physiol. 2019 Jan;597(2):399-418. doi: 10.1113/JP277360.
PMID: 30412283 PMCID: PMC6332759


Super-resolution and Confocal Microscopy

Our institute is one of the nodes in a core facility for super-resolution and confocal microscopy supported by Helse Sør-Øst. This core facility includes two additional nodes located at Radiumhospitalet (Montebello) and Rikshospitalet (Gaustad).

A core facility is a laboratory with particularly advanced equipment that serves researchers both within and outside the unit.

Read more about:
Core Facility Super-resolution and Confocal Microscopy, Ullevål


K. G. Jebsen Centre for Cardiac Research at University of Oslo

K.G. Jebsen Centre for Cardiac Research is directed by Professor Ivar Sjaastad: "Our primary objective is to better understand the mechanisms of heart failure. Specifically, we will identify mechanisms regulating myocardial stiffness, and new therapeutic targets of diastolic dysfunction."

The centre comprises six research groups at University of Oslo; of which three are located at Ullevål Hospital, two at Rikshospitalet and one at Radiumhospitalet.

Group leaders: Ivar Sjaastad (Centre leader), Geir Christensen, (Deputy leader), William E. Louch, Camilla Raiborg, Thor Edvardsen and Lars Gullestad
Associated partners: Alessandro Cataliotti, Llewelyn Roderick (University of Cambridge), Joakim Sundnes (Simula) and Kjetil Taskén
Administrative coordinator: Emil Espe

Read more about the K.G. Jebsen Centre for Cardiac Research

Institute for Experimental Medical Research (IEMR)

Institutt for eksperimentell medisinsk forskning (IEMF)

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www.iemf.no www.iemr.no


Institute for Experimental
Medical Research (IEMR)

use cutting edge technologies to better understand the mechanisms of heart failure.

Our method competency is comprehensive, and streches from clinical studies to investigation of individual biomolecules.

Excellent science reveals the secrets of the failing heart

Find novel targets for the treatment of heart failure patients.
Develop and employ cutting edge technologies to understand the mechanisms of heart failure.
Recruit and educate PhD and medical students to become tomorrow’s scientific experts.

Webmaster Vidar, IEMF