Molecular mechanisms of signal transduction in heart

Cathrine Carlson 5x7

My research group focuses on defining molecular mechanisms and the intracellular communication networks that promote specificity in signal transduction in the heart. In particular, we work on various ion channels and exchangers, proteoglycans, kinases and phosphatases and changes in these protein complexes during development of heart failure (illustrated in figure 1 below).

In our projects we use a range of molecular biology techniques combined with peptide technology. In particular, we identify various protein interactomes and protein-protein interactions down to the amino acid level to further develop high affinity peptide disruptors to block harmful signaling events (pro-drugs, illustrated in figure 2 below). The peptide disruptors are introduced into various cell cultures and primary cardiac cells by adding a cell-permeable tag or into animals by adeno-associated virus technology or by making transgenic animals.

We have several top-of-the-range national and international collaborators.

See Carlson research group

Figure 1: (Finsen et al., Plos One, 6(12):e28302, 2011)

Figure 2: (Wanichawan et al.,Biochem J, 473(15):2413-23, 2016)

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